Results 51 to 60 of about 51,586,577 (251)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
EDUCATIONAL AUTONOMY AS AN IMPORTANT PREREQUISITE FOR THE FORMATION OF FUTURE PHDS’ RESEARCH COMPETENCE IN THE CONDITIONS OF POSTGRADUATE STUDIES [PDF]
Вісник Університету імені Альфреда Нобеля. Серія Педагогіка і психологияThe trend of student-centred education in higher education institutions imposes new requirements on standards within the achievement of professional competencies.
Oliinyk Iryna
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pupils language competence in the primary school literature review [PDF]
, 2015 This paper, which forms part of an ongoing PhD study, attempts a summary overview of research on pupil competence in modern languages in the primary school, as presented by a Systematic Literature Review (SLR).
Kanaki, Argyro; id_orcid
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Advancing genomics research in Ireland. Irish Health Research Forum report and recommendations [PDF]
, 2021 This report presents the proceedings of the Irish Health Research Forum meeting on Thursday 12th November 2020 and makes key recommendations for for advancing genomics research in ...
Health Research Charities Ireland
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Scaffolding recommendations for students’ essay planning
Frontiers in EducationPlanning scientific essays is a fundamental activity for students to acquire and demonstrate research competence in higher education. The planning and writing process is complex and time-consuming, requiring significant effort from both students and ...
Lars van Rijn +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Manifesto for medical research [PDF]
, 2015 The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source