Results 111 to 120 of about 2,686,106 (243)

Russian Science and Russian State: Image of a Scientist in Modern Russian Cinema

open access: yesVestnik MGIMO-Universiteta, 2014
The article analyses the image of a scientist represented in recent Russian movies. The article discusses two groups of questions: (1) nature and role of popular science in the life of society; (2) national features of scientific cultures.
Svetlana M. Medvedeva
doaj  

Recommendations for empowering early career researchers to improve research culture and practice. [PDF]

open access: yesPLoS Biol, 2022
Kent BA   +47 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Evaluation of the research capacity and culture of allied health professionals in a large regional public health service

open access: yesJournal of Multidisciplinary Healthcare, 2019
Janine Matus,1 Rachel Wenke,1 Ian Hughes,1 Sharon Mickan1,2 1Allied Health, Gold Coast Health, Gold Coast, QLD, Australia; 2School of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia Purpose: The first aim of this study was to ...
Matus J, Wenke R, Hughes I, Mickan S
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

An emerging TIMER-2C framework for addressing barriers to research culture and productivity among local healthcare providers in the Middle East and sub-Saharan Africa: A qualitative study and modified Delphi approach. [PDF]

open access: yesPLOS Glob Public Health
Odeny B   +12 more
europepmc   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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