Results 111 to 120 of about 7,390,753 (310)

The Effect Analysis of Motivation, Competence and Organizational Culture on Employees Performance of Jakarta Social Department [PDF]

open access: yes, 2019
All this time, government institutions are still overshadowed by stigma, the poor performance of civil servants. Therefore, this research was conducted to analyze the influence of performance factors, including motivation, competence and organizational ...
Finatariani, E. (Endah)
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Emerging Religious Marketplace in Nigeria: A Quest for Interpretation [PDF]

open access: yes, 2014
In contemporary Nigerian society, the evolving trends in Christian religious culture suggest that neoliberal (social) mind-set is influencing certain practices in many Churches.
Duke, Emmanuel Orok
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

A roadmap to good practice for training supervisors and leadership: a European perspective

open access: yesFrontiers in Research Metrics and Analytics
PurposeSupervision and leadership are regarded to have a major role in promoting responsible research. Various approaches to training for supervisors and leaders have been proposed. However, little is known about what works best, what kind of hurdles are
Seán Lacey   +5 more
doaj   +1 more source

Research and Pedagogy in Intercultural New Media Studies [PDF]

open access: yes, 2012
New media are ubiquitous, changing the landscape of intercultural communication. Intercultural new media studies (INMS), first introduced and conceptualized by Robert Shuter in 2012 in his article in the Journal of Intercultural Communication Research ...
Shuter, Robert
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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