Results 131 to 140 of about 56,063,487 (256)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Russian Science and Russian State: Image of a Scientist in Modern Russian Cinema

Vestnik MGIMO-Universiteta, 2014
The article analyses the image of a scientist represented in recent Russian movies. The article discusses two groups of questions: (1) nature and role of popular science in the life of society; (2) national features of scientific cultures.
Svetlana M. Medvedeva
doaj  

Recommendations for empowering early career researchers to improve research culture and practice. [PDF]

PLoS Biol, 2022
Kent BA, Holman C, Amoako E, Antonietti A, Azam JM, Ballhausen H, Bediako Y, Belasen AM, Carneiro CFD, Chen YC, Compeer EB, Connor CAC, Crüwell S, Debat H, Dorris E, Ebrahimi H, Erlich JC, Fernández-Chiappe F, Fischer F, Gazda MA, Glatz T, Grabitz P, Heise V, Kent DG, Lo H, McDowell G, Mehta D, Neumann WJ, Neves K, Patterson M, Penfold NC, Piper SK, Puebla I, Quashie PK, Quezada CP, Riley JL, Rohmann JL, Saladi S, Schwessinger B, Siegerink B, Stehlik P, Tzilivaki A, Umbers KDL, Varma A, Walavalkar K, de Winde CM, Zaza C, Weissgerber TL.   +47 more
europepmc   +1 more source

Bivalve mollusc culture research in Thailand [PDF]

An account of research, which explored new biological and socioeconomic perspectives on bivalve mollusc culture to increase production and to improve the livelihood of farmers.
Chongpeepien, T. (eds.), McCoy, E.W.
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluation of the research capacity and culture of allied health professionals in a large regional public health service

Journal of Multidisciplinary Healthcare, 2019
Janine Matus,1 Rachel Wenke,1 Ian Hughes,1 Sharon Mickan1,2 1Allied Health, Gold Coast Health, Gold Coast, QLD, Australia; 2School of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia Purpose: The first aim of this study was to ...
Matus J, Wenke R, Hughes I, Mickan S
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Five ways team leaders can improve research culture. [PDF]

Nat Rev Mater, 2021
Ayres Z.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

An emerging TIMER-2C framework for addressing barriers to research culture and productivity among local healthcare providers in the Middle East and sub-Saharan Africa: A qualitative study and modified Delphi approach. [PDF]

PLOS Glob Public Health
Odeny B, Mangale D, Sharma D, Balogun M, Bukusi E, Suleman F, Derbew M, Iwelunmor J, Birru E, Ngang IC, Anandarajah A, Mamillapalle V, Almahmeed W.   +12 more
europepmc   +2 more sources