Results 131 to 140 of about 7,390,753 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

THE ROLE OF LOCAL LANGUAGE IN NATION’S CHARACTER BUILDING* [PDF]

open access: yes, 2017
There are much complex cultures appeared as the result of “paradigm process in a modern era. New dimensions are fruitful until all experiences and sciences become relative because they tend to be the result of human activity.
Citraresmana, Elvi   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Safety culture at a local organisation [PDF]

open access: yes, 2018
New Zealand is facing a serious issue each week, there are 16 loved ones who cannot go home due to occupational health and safety related accidents and diseases; each year, on average we lose 600-900 people to workplace health and safety related ...
Davis-Ngatai , Priscilla S.T.   +1 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Examining the Evolution and Components of the Culture of Learning in University Education: A Systematic Scoping Review

open access: yesJournal of Language and Education
Introduction: The term "culture of learning" frequently appears in research on educational development and reform, yet defining it precisely remains challenging.
Tatiana Laguttseva-Nogina   +3 more
doaj   +1 more source

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