Results 121 to 130 of about 56,063,487 (256)

Conference on Culture, Cultural Modeling, Counterinsurgency and Conflict Behavior [PDF]

, 2009
"An assorted mix of cultural experts, anthropologists, sociologists, government officials, and analysts convened on March 24th and 25th at the Naval Postgraduate School in Monterey California to discuss the impact culture has in both conflict behavior ...
Kaufmann, Sarah, Dearing, Matt, DuPee, Matt   +2 more
core   +1 more source

Impact Agenda and Practices of Inclusion and Reward for Early Career Researchers in the Social Sciences and Humanities

Social Inclusion
This article explores some effects of the “impact agenda” on early academic careers and knowledge production. The impact agenda is the incentivisation of socio‐economic impact in university‐based research through research funding and evaluation ...
Sanja Djerasimovic, Jenny Barke
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Policies, incentives, and faculty participation in the Institutional sustainability of public higher education in Panama

Frontiers in Education
This qualitative study analyzes determining factors in the achievement of scientific and academic research in Panama’s public universities through methodological and data triangulation.
Gabisel Barsallo, Gabisel Barsallo, Elisa Mendoza, Ricardo Caballero, Emerson Devia-Acevedo   +4 more
doaj   +1 more source

Editorial: Open when, why, to whom? Changing challenges, perspectives and practices in a new research culture. [PDF]

Front Res Metr Anal, 2023
Mugnaini R, Fradkin C, Urs S.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Embedding Research Culture in Community Hospitals. [PDF]

Intern Med, 2022
Iwata H, Kaneko M, Wakabayashi T, Ueda S.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Enhancing research culture through PhD training: a systems approach to identifying leverage points for policy formation. [PDF]

Wellcome Open Res, 2023
Martin R, Nasir N, Carusi A.
europepmc   +1 more source