Results 51 to 60 of about 2,686,106 (243)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Data-Driven Insights for a Holistic Understanding of Research Culture

open access: yesExchanges
Research environments (and their measurement and tracking) are becoming increasingly complex, with rapid Artificial Intelligence (AI) advancements, interdisciplinary collaboration, and global connectivity shaping the way research knowledge is created ...
Ann Campbell   +2 more
doaj   +1 more source

Profile Analysis of Faculty-Researchers in STEM Education in a Philippine University

open access: yesJournal of EST (Educational Science And Technology), 2020
The aim of this study is to create a deeper analysis of the individual backgrounds of higher education educators who are involved in research on Science, Technology, Engineering, and Mathematics (STEM) in a state university in the Philippines.
Bryan Mallillin Nozaleda   +1 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Time Poverty and its Impact on Research Culture

open access: yesExchanges
This article, based on our experience carrying out research culture surveys at our respective universities, discusses how ‘time poverty’ represents a significant challenge to the creation of positive research cultures.
Karin Wahl-Jorgensen, Candy Rowe
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The Moral Dimension to Developing Research Culture

open access: yesExchanges
The paper seeks to justify a moral dimension to research culture, both in terms of the moral commitment to pursuing a shared sense of purpose by researchers, and a moral obligation to provide a positive environment for researchers to flourish in by the ...
Aidan Thompson
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The More the Merrier

open access: yesExchanges
Researcher developers today are expected to be able to support researchers at a variety of different career stages, all of whom have increasingly varying needs and identities.
Taryn Bell   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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