Results 61 to 70 of about 56,063,487 (256)

GDPR and health research: stakeholder voices. Data protection and health research - what does the legislation mean for patients, the public and the research community? Report and recommendations. [PDF]

open access: yes, 2018
This report presents the proceedings of the Irish Health Research Forum on November 14th 2018 focusing on data protection legislation and health research, and the implications for patients, the public and researchers.
Medical Research Charities Group
core  

The impact of Covid-19 on health research charities

open access: yes, 2021
HRCI conducted a survey of its members in December 2020 to ascertain the impact of Covid-19 on Irish Health Research Charities.
Health Research Charities Ireland, /
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Time Poverty and its Impact on Research Culture

open access: yesExchanges
This article, based on our experience carrying out research culture surveys at our respective universities, discusses how ‘time poverty’ represents a significant challenge to the creation of positive research cultures.
Karin Wahl-Jorgensen, Candy Rowe
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

The Moral Dimension to Developing Research Culture

open access: yesExchanges
The paper seeks to justify a moral dimension to research culture, both in terms of the moral commitment to pursuing a shared sense of purpose by researchers, and a moral obligation to provide a positive environment for researchers to flourish in by the ...
Aidan Thompson
doaj   +1 more source

2016–17 Institute for Culture and Society Annual Review

open access: yes, 2017
In 2016, researchers in the Institute for Culture and Society (ICS) were active participants in national and global debates about the nature of globalisation, the meaning of cultural difference and crosscultural engagement, the future of cities, the ...
Barcham, Helen (18966)   +1 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

The More the Merrier

open access: yesExchanges
Researcher developers today are expected to be able to support researchers at a variety of different career stages, all of whom have increasingly varying needs and identities.
Taryn Bell   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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