Results 71 to 80 of about 7,390,753 (310)

Agricultural Turns, Geographical Turns: Retrospect and Prospect. [PDF]

open access: yes, 2004
It is accepted that British rural geography has actively engaged with the ‘cultural turn’, leading to a resurgence of research within the sub-discipline. However, a reading of recent reviews suggests that the cultural turn has largely, if not completely,
Arensberg   +133 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The application of Han Dynasty cultural elements to modern product design [PDF]

open access: yes, 2014
Chinese Han Culture, as Chinese nation's "core culture", is the cultural symbol of Chinese nation, and played an important role in the history of Chinese cultural development, even in the history of world cultural development.
Chen, L   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Bivalve mollusc culture research in Thailand [PDF]

open access: yes
An account of research, which explored new biological and socioeconomic perspectives on bivalve mollusc culture to increase production and to improve the livelihood of farmers.
Chongpeepien, T. (eds.), McCoy, E.W.
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Developing a culture of evaluation and research [PDF]

open access: yes
Increasingly, organisations are expected to demonstrate, and document, the differences their services are making for children, families and communities (McCoy, Rose, & Connolly, 2013; 2014).
Jacqueline Stewart
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Russian Science and Russian State: Image of a Scientist in Modern Russian Cinema

open access: yesVestnik MGIMO-Universiteta, 2014
The article analyses the image of a scientist represented in recent Russian movies. The article discusses two groups of questions: (1) nature and role of popular science in the life of society; (2) national features of scientific cultures.
Svetlana M. Medvedeva
doaj  

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