Results 151 to 160 of about 74,522,906 (314)
HRB Policy on Management and Sharing of Research Data v.1.0
, 2019 This policy is intended to promote the responsible management and sharing of research data, and the software and materials that underpin its use, with as few restrictions as possible to maximise its value for research and for patient and public benefit.
Health Research Board
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Longitudinal Survey on Rural Urban Migration in China
The Longitudinal Survey on Rural Urban Migration in China (RUMiC) consists of three parts: the Urban Household Survey, the Rural Household Survey and the Migrant Household Survey.
Australian National University (ANU) +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Manifesto for medical research [PDF]
, 2015 The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
core
Evaluation of data repositories based on the FAIR Principles for IDCC 2017 practice paper
, 2017 Corresponding data-set to IDCC 2017 Practice Paper 'Are the FAIR-Principles fair?'. Excel Spreadsheet with overview and categories, frequency and proportion statistics, and graphs of 37 data repositories in the Netherlands and Europe.
de Smaele, M.M.E. (Madeleine) +2 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Adoption of an electronic patient record sharing pilot project: cross-sectional survey
This data archive contains the data that supplement the manuscript in Journal of Medical Internet Research titled “Adoption of an electronic patient record sharing pilot project: cross-sectional survey”.
Wang, Jingxuan +5 more
core +1 more source