Results 21 to 30 of about 713,990 (260)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Research Data Alliance (RDA) and the Social Sciences

, 2021
The Research Data Alliance (RDA, www.rd-alliance.org) is an international organization aiming to develop infrastructure and community activities that enable open sharing of data. The RDA operates across the globe and connects research data experts (like researchers, data stewards, librarians and funders) from a variety of disciplines, including the ...
openaire   +2 more sources

The research data alliance – A global collaboration forum to tackle data challenges

, 2021
ABSTRACT / INTRODUCTIONThe Research Data Alliance (RDA) [1], a community-driven initiative with the goal of building the social and technical infrastructure to enable open sharing and re-use of data, currently has over 11,000 members - including data scientists, librarians, researchers, funders, policy makers - from more than 140 countries [2].
Kethers, Stefanie, Treloar, Andrew
openaire   +1 more source

Effect of volcanic dykes on coastal groundwater flow and saltwater intrusion : a field-scale multiphysics approach and parameter evaluation [PDF]

, 2017
Acknowledgments This research was primarily based on research grant‐aided by the Irish Department of Communications, Energy and Natural Resources under the National Geoscience Programme 2007–2013.
A. González-Quirós, Abarca, Abdul Nassir, Archie, Arps, Attwa, Babiker, Beaujean, Bense, Berkowitz, Boehmer, Boonstra, Bourhane, Bouwer, Bromley, C. Wilson, Carrera, Comte, Comte, Comte, Cook, Cooper, Cooper, Cronin, Custodio, Dam, Dickson, Dickson, Dogan, Earls, Engel, Engel, Ernst, Erskine, European Commission, Fetter, Günther, Hartley, Healy, Herckenrath, Herckenrath, Izquierdo, J.-C. Comte, Jacob, Kalin, Kirkegaard, Koukadaki, Linde, Marsily, McKinley, McNeill, Mitchell, Moench, Moench, Morel, Neuman, Nguyen, Oldenburg, Parasnis, Perrin, Post, Revil, Rücker, Sami, Si, Simmons, Singhal, Souza, Sultan, Summer, Takasaki, Taylor, U. Ofterdinger, Vittecoq, Vittecoq, Waxman, Werner, Wilkes, Yang, Zheng   +79 more
core   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The Long Term Effects of a 12‐Session Community Exercise Program on Health Measures in Cancer Patients

Aging and Cancer, EarlyView.
ABSTRACT Purpose To assess the long‐term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non‐metastatic and metastatic patients.
Isaac Oppong, Roozbeh Naemi
wiley   +1 more source

Archiving the Legacy of the Research Data Alliance [PDF]

, 2016
The multitude of working, interest, and coordinating groups in the Research Data Alliance (RDA) generate many digital objects that do not currently benefit from a coherent management strategy.
Dunham, Elise
core  

Classification of Southern Ocean krill and icefish echoes using random forests [PDF]

, 2016
Acknowledgements The authors thank the crews, fishers, and scientists who conducted the various surveys from which data were obtained. This work was supported by the Government of South Georgia and South Sandwich Islands.
Fallon, Niall G., Fernandes, Paul G., Fielding, Sophie   +2 more
core   +1 more source

An extension to the OVH concept for knowledge‐based dose volume histogram prediction in lung tumor volumetric‐modulated arc therapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Volumetric‐modulated arc therapy (VMAT) treatment planning allows a compromise between a sufficient coverage of the planning target volume (PTV) and a simultaneous sparing of organs‐at‐risk (OARs). Particularly in the case of lung tumors, deciding whether it is possible or worth spending more time on further improvements of a treatment
Johann Brand, Juliane Szkitsak, Oliver J. Ott, Christoph Bert, Stefan Speer   +4 more
wiley   +1 more source

Therapeutic alliance : exploration of the construct validity of the concept [PDF]

, 2014
Background: Repeated meta-analyses have established that there exists a robust association between therapeutic alliance and outcome at end of treatment; still, there is a lack of coherent theory regarding the concept and lack of agreement on how to ...
Lindgren, Annika
core   +1 more source