Results 41 to 50 of about 64,613,075 (301)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A combination sampling approach for epidemiologic research in humanitarian settings: a case analysis of a study of depressive disorder prevalence among refugees in Greece

BMC Public Health, 2021
Background Understanding the burden of common mental health disorders, such as depressive disorder, is the first step in strengthening prevention and treatment in humanitarian emergencies.
Danielle N. Poole, Nathaniel A. Raymond, Jos Berens, Mark Latonero, Julie Ricard, Bethany Hedt-Gauthier   +5 more
doaj   +1 more source

Initiative to establish Research Data Alliance moves forward [PDF]

Eos, Transactions American Geophysical Union, 2012
With the amount of scientific data being gathered growing exponentially—due to the increasing number of sensor networks, scientific instruments, computer models, and other tools—there are enormous scientific opportunities but also significant challenges, including how to effectively share research data within and across scientific communities.
openaire   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Knowledge Access through Libraries in the United Digital Market

Digital Presentation and Preservation of Cultural and Scientific Heritage, 2022
The European Open Science Cloud and the strategy for unified digital market are corner stones in the way of Europe's economy, industry, and society to the new digital era.
Eliza Stefanova, Krassen Stefanov
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Research Data Alliance

, 2016
To appear in the proceedings of Astronomical Data Analysis Software and Systems XXV (ADASS XXV), a conference held 25-29 October 2015 at Sydney, Australia. Edited by N. P. F. Lorente, & K. Shortridge (San Francisco: ASP)
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Pan Africa Bean Research Alliance 2015-2020 Results

, 2022
Pan Africa Bean Research Alliance (PABRA) has been over 25 years working with partners in 31 countries to breed better beans for Africa through agricultural research for ...
Pan-Africa Bean Research Alliance
core   +1 more source

Research Data Alliance Hybridisation of Plenaries

, 2023
This document outlines detailed processes to assist with planning hybrid events. The document includes reflections and definitions of what a hybrid event looks like and what to expect during the planning preparation. It covers online and in-person arrangement elements.
Hope, Irina, Bustamente, Alejandra, Underwood, Meghan   +2 more
openaire   +1 more source