Results 51 to 60 of about 805,667 (305)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Archiving the Legacy of the Research Data Alliance [PDF]

, 2016
The multitude of working, interest, and coordinating groups in the Research Data Alliance (RDA) generate many digital objects that do not currently benefit from a coherent management strategy.
Dunham, Elise
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Assessing consistency of fish survey data : uncertainties in the estimation of mackerel icefish (Champsocephalus gunnari) abundance at South Georgia [PDF]

, 2015
Acknowledgments The authors wish to thank the crews, fishermen and scientists who conducted the various surveys from which data were obtained, and Mark Belchier and Simeon Hill for their contributions.
Collins, Martin A., Fallon, Niall G., Fernandes, Paul G., Marshall, C. Tara   +3 more
core   +1 more source

3 tera-basepairs as a fundamental limit for robust DNA replication [PDF]

, 2020
10 p.-2 tab.In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly ...
Al Mamun, M., Albergante, L., Blow, J. J., Newman, T. J.   +3 more
core   +3 more sources

The Research Data Alliance

, 2016
To appear in the proceedings of Astronomical Data Analysis Software and Systems XXV (ADASS XXV), a conference held 25-29 October 2015 at Sydney, Australia. Edited by N. P. F. Lorente, & K. Shortridge (San Francisco: ASP)
openaire   +2 more sources

Research Data Alliance (RDA) and the Social Sciences

, 2021
The Research Data Alliance (RDA, www.rd-alliance.org) is an international organization aiming to develop infrastructure and community activities that enable open sharing of data. The RDA operates across the globe and connects research data experts (like researchers, data stewards, librarians and funders) from a variety of disciplines, including the ...
openaire   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Towards standardised cross-sectoral agreements for data depositing and data access in Trusted Research Environments: streamlined contracting to advance public benefit research. 

International Journal of Population Data Science
Objective  Trusted Research Environments (TREs) rely on Data Contributor Agreements (DCAs) and Data Access Agreements (DAAs) to bind organisations to terms and conditions in place to protect data.
Rachel Brophy, Cassie Smith, Andy Boyd, Pan UK Data Governance Steering Group   +3 more
doaj   +1 more source