Results 121 to 130 of about 8,960,592 (314)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

FAIR research data management as community approach in bioengineering. [PDF]

Eng Life Sci, 2023
Rehnert M, Takors R.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Data Sharing: International and National Approaches

Iranian Journal of Information Processing & Management, 2018
Information and Communication Technologies (ICTs) have significant role in producing research data in different scientific fields. These data not only lead to generates fields based on research data but also caused to produce a new paradigm or approach ...
Esmaeil Vaziri, ,
doaj  

The State of Dissemination of Open Research Data in Ukraine and the World: Bibliometric Analysis

European Journal of Management Issues, 2021
Purpose: To determine the current state of development of open science in the paradigm of open research data in Ukraine and the world, as well as to analyze the representation of Ukraine in the world research space, in terms of research data exchange.
Anton Boiko, Olha Kramarenko, Sardar Shabanov   +2 more
doaj  

A focus groups study on data sharing and research data management. [PDF]

Sci Data, 2022
Donaldson DR, Koepke JW.
europepmc   +1 more source

Data management for community research projects: A JGOFS case study [PDF]

Since the mid 1980s, much of the marine science research effort in the United Kingdom has been focused into large scale collaborative projects involving public sector laboratories and university departments, termed Community Research Projects.
Lowry, Roy K.
core   +1 more source

E-Learning Strategies in Developing Research Performance Efficiency: Higher Education Institutions [PDF]

, 2019
The study aimed to identify E- Learning strategies and their relation to the efficiency of research performance in foreign and Palestinian universities (University of Ottawa, Munster, Suez Canal, Al-Azhar, Islamic, Al-Aqsa).
Abdalmenem, Samia A. M., Amuna, Youssef M. Abu, Arqawi, Samer M., Naser, Samy S. Abu, Shobaki, Mazen J. Al   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The genotype list string code syntax for exchanging nomenclature-level genotyping results in clinical and research data management and analysis systems. [PDF]

HLA, 2023
Mack SJ, Sauter J, Robinson J, Osoegawa K, McKenzie L, Schneider J, Maiers M, Milius RP.   +7 more
europepmc   +1 more source