Results 71 to 80 of about 654,709 (293)
Architectural Research Quarterly, 2017 Early issues of arq in the mid-1990s were preoccupied with the possibilities for researching architecture through design: how design research might be constituted and communicated, and – practically for architecture schools at that time – how design might be counted as research in the newly-introduced metrics used to judge research quality in UK ...
openaire +2 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Architecture and the Built Environment, 2019 The following research questions are going to be answered to reveal the characteristics of TiB and their present state of sustainability and the potential for future sustainability to inform regional planning and design: What spatial structures characterise dispersed urban areas in Europe?
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FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Politics and Governance, 2013 The vast literature on party identification has gradually become bogged down by disputes about how to interpret observational data. This paper proposes the use of experimental designs to shed light on the responsiveness of party identification to short ...
Donald P. Green
doaj +1 more source
A Design Space of Vision Science Methods for Visualization Research [PDF]
arXiv, 2020 A growing number of efforts aim to understand what people see when using a visualization. These efforts provide scientific grounding to complement design intuitions, leading to more effective visualization practice. However, published visualization research currently reflects a limited set of available methods for understanding how people process ...
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Discussion: “Modern Steam Passenger Locomotives—Research and Design” (Kiefer, P. W., 1942, Trans. ASME, 64, pp. 1–13) [PDF]
, 1942 J. E. Partington
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The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source