Results 81 to 90 of about 2,632,433 (266)

How Maps Shape Information in Design Research: A Study of Five Method Collections [PDF]

Maps have a rich history in design and design research. However, to date, their use and application have not been systematically studied. This paper proposes a model that classifies maps into four main types depending on how they help designers to ...
Koskinen, I, Tomitsch, Martin, Koskinen, Ilpo, Tomitsch, M   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Design-Based Research [PDF]

, 2015
Educational design research is a genre of research in which the iterative development of solutions to practical and complex educational problems provides the setting for scientific inquiry. The solutions can be educational products, processes, programs or policies.
Reeves, Thomas, McKenney, Susan
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Methodology in Research on Speech Patterns

Journal of Modern Languages, 2017
This study considers the concept of methodology, in which the methodology is a term that is used to refer basically to methods involved in testing a hypothesis or finding answers to a research question.
Nicole Wong
doaj  

The use of control group in research design: the ethical challenge in the population with intellectual and developmental disabilities

Motricidade
Ethics studies moral values and defines good and bad conduct in research and researchers. In the area of research with human beings, it plays a crucial role in imposing limits, reducing abuses, and providing fair lines of research.
Susana Diz, Miguel Jacinto, Diogo Monteiro, Rui Matos, Dulce Esteves, Aldo Matos da Costa, Raul Antunes   +6 more
doaj   +1 more source

Physiological measurements of drawing and forming activities [PDF]

, 2016
The embodiment of tools and experiential knowledge of materials gained over time lies at the heart of both design and craft practices. However, empirical studies combining the study of mind and body in relation to design and craft practice is in its ...
Groth, Camilla, Mimmu Rankanen, Rankanen, Mimmu, Camilla Groth, Pirita Seitamaa-Hakkarainen, Maarit Mäkelä, Seitamaa-Hakkarainen, Pirita, Mäkelä, Maarit, Huotilainen, Minna, Marianne Leinikka, Minna Huotilainen, Leinikka, Marianne   +11 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Teaching design for sustainability from the classroom: Uncomfortable reflections from a comfortable place

, 2023
The paper describes co-teaching on a masters programme with design for sustainability at its core. The programme puts emphasis on involving multiple societal stakeholders but increasingly also on appreciating the often tricky social and value-laden ...
Berglund, Eeva
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source