Results 41 to 50 of about 52,407,333 (239)

Advancing genomics research in Ireland. Irish Health Research Forum report and recommendations [PDF]

, 2021
This report presents the proceedings of the Irish Health Research Forum meeting on Thursday 12th November 2020 and makes key recommendations for for advancing genomics research in ...
Health Research Charities Ireland
core  

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Attention-deficit/hyperactivity disorder: An integrated developmental psychopathology and Research Domain Criteria (RDoC) approach

Comprehensive Psychiatry, 2019
Attention-deficit/hyperactivity disorder (ADHD) is characterized by heterogeneous behaviors and symptoms, developmental trajectories, and treatment response.
Erica D. Musser, Joseph S. Raiker, Jr.
doaj   +1 more source

Intrication des techniques et des enjeux épistémologiques au sein du projet des Research Domain Criteria 

Cahiers François Viète, 2023
The Research Domain Criteria (RDoC) project is a psychiatry research plan aiming to foster the development of neuroscientific and behaviour sciences knowledge by getting rid of the diagnostic systems most used nowaday.
Elodie Gratreau
doaj   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Research Diagnostic Criteria For Infants And Preschool Children: The Process And Empirical Support

, 2003
Systematic research on psychiatric disorders in infants and preschool children (0–5 years old) has lagged considerably behind that for older children, adolescents, and adults.
Task Force On Research Diagnostic Criteria: Infancy And Preschool,
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Research Domain Criteria (RDoC) domains positive valence system, negative valence system, cognitive systems, and social processes and their relationship with stress, anxiety, and depressive symptoms in a university student sample

Frontiers in Psychiatry
IntroductionMental health difficulties are highly prevalent among university students. The Research Domain Criteria (RDoC) framework seeks to improve diagnosis, treatment, and prevention by providing a comprehensive framework for understanding mental ...
Veronika Esipova, Mira Tschorn, Mira Tschorn, Sarah J. Böttger, Sarah J. Böttger, Julia Seiffert, Bernd Förstner, Bernd Förstner, Timm Seegert, Michael A. Rapp, Michael A. Rapp, Kristin Koller-Schlaud   +11 more
doaj   +1 more source

The Atlas of Australia Online 2023 [PDF]

, 2023
The Atlas of Australia Online 2023 research report provides a contemporary atlas of the Australian internet, and reveals important insights into the digital landscape of Australia. It does so by augmenting the .au Domain Administration (auDA) domain name
Gong, X, Griffith, C, McCarthy, Paul X ; https://orcid.org/, McFarland, C   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source