Results 51 to 60 of about 52,407,333 (239)

Examining the independent and combined effects of autistic and ADHD traits on multisensory integration

Frontiers in Human Neuroscience
Multisensory integration differences have been reported in individuals with Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD), yet little is known about how these traits may jointly influence multisensory processing ...
Carolynn Hare, Carolynn Hare, Carolynn Hare, Carolynn Hare, Michelle Luszawski, Michelle Luszawski, Michelle Luszawski, Samantha E. Schulz, Yassmine Arnaout, Ryan A. Stevenson, Ryan A. Stevenson, Ryan A. Stevenson, Ryan A. Stevenson   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Transsemptomatic Diagnosis as a Replacement for Transdiagnostic Approach in Psychiatry

Psikiyatride Güncel Yaklaşımlar
Traditionally, the DSM and ICD diagnostic systems have been based on the principle that mental disorders are separate diseases with different etiologies and clinical manifestations.
Osman Özdemir
doaj   +1 more source

The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders

Frontiers in Psychiatry, 2023
BackgroundAnxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental ...
Bernd R. Förstner, Sarah Jane Böttger, Alexander Moldavski, Malek Bajbouj, Andrea Pfennig, André Manook, Marcus Ising, Andre Pittig, Andre Pittig, Ingmar Heinig, Andreas Heinz, Klaus Mathiak, Klaus Mathiak, Thomas G. Schulze, Thomas G. Schulze, Thomas G. Schulze, Frank Schneider, Frank Schneider, Inge Kamp-Becker, Andreas Meyer-Lindenberg, Frank Padberg, Tobias Banaschewski, Michael Bauer, Rainer Rupprecht, Hans-Ulrich Wittchen, Hans-Ulrich Wittchen, Michael A. Rapp, Mira Tschorn   +27 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Reproducible Effects of Sex and Acquisition Order on Multiple Global Signal Metrics: Implications for Functional Connectivity Studies of Phenotypic Individual Differences Using fMRI

Brain and Behavior
Purpose The identification of relationships between individual differences in functional connectivity (FC) and behavior has been the focus of considerable investigation.
Henry W. Chase, Danella M. Hafeman, Merage Ghane, Alexander Skeba, Tyler Brady, Haris A. Aslam, Richelle Stiffler, Lisa Bonar, Simona Graur, Genna Bebko, Michele Bertocci, Satish Iyengar, Mary L. Phillips   +12 more
doaj   +1 more source

The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes

BMC Psychiatry, 2020
Background A major research finding in the field of Biological Psychiatry is that symptom-based categories of mental disorders map poorly onto dysfunctions in brain circuits or neurobiological pathways.
Tanja M. Brückl, Victor I. Spoormaker, Philipp G. Sämann, Anna-Katharine Brem, Lara Henco, Darina Czamara, Immanuel Elbau, Norma C. Grandi, Lee Jollans, Anne Kühnel, Laura Leuchs, Dorothee Pöhlchen, Maximilian Schneider, Alina Tontsch, Martin E. Keck, Leonhard Schilbach, Michael Czisch, Susanne Lucae, Angelika Erhardt, Elisabeth B. Binder   +19 more
doaj   +1 more source

Integrating NIMH Research Domain Criteria (RDoC) into PTSD Research

, 2017
Three and a half decades of research on posttraumatic stress disorder (PTSD) has produced substantial knowledge on the pathobiology of this frequent and debilitating disease. However, despite all research efforts, so far no drug that has specifically targeted PTSD core symptoms progressed to clinical use.
Schmidt, U., Vermetten, E.
openaire   +3 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source