Results 51 to 60 of about 2,205,527 (302)

Rethinking the risk for depression using the RDoC: A psychophysiological perspective

Frontiers in Psychology, 2023
Considering that the classical categorical approach to mental disorders does not allow a clear identification of at-risk conditions, the dimensional approach provided by the Research Domain Criteria (RDoC) is useful in the exploration of vulnerability to
Carola Dell’Acqua, Carola Dell’Acqua, Daniela Palomba, Daniela Palomba, Elisabetta Patron, Simone Messerotti Benvenuti, Simone Messerotti Benvenuti, Simone Messerotti Benvenuti   +7 more
doaj   +1 more source

PsyCoP – A Platform for Systematic Semi-Automated Behavioral and Cognitive Profiling Reveals Gene and Environment Dependent Impairments of Tcf4 Transgenic Mice Subjected to Social Defeat

Frontiers in Behavioral Neuroscience, 2021
Recently, hundreds of risk genes associated with psychiatric disorders have been identified. These are thought to interact with environmental stress factors in precipitating pathological behaviors.
Paul Volkmann, Marius Stephan, Marius Stephan, Sven Krackow, Niels Jensen, Moritz J. Rossner   +5 more
doaj   +1 more source

Impaired Evidence Accumulation as a Transdiagnostic Vulnerability Factor in Psychopathology

Frontiers in Psychiatry, 2021
There is substantial interest in identifying biobehavioral dimensions of individual variation that cut across heterogenous disorder categories, and computational models can play a major role in advancing this goal.
Chandra Sripada, Alexander Weigard
doaj   +1 more source

Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders (MIND-SET): Protocol for a Cross-sectional Comorbidity Study From a Research Domain Criteria Perspective

JMIRx Med, 2021
Background It is widely acknowledged that comorbidity between psychiatric disorders is common. Shared and diverse underpinnings of psychiatric disorders cannot be systematically understood based on symptom-based categories of mental disorders, which map ...
P. V. van Eijndhoven, R. Collard, J. Vrijsen, Dirk E. M. Geurts, A. Vasquez, A. Schellekens, Eva van den Munckhof, S. Brolsma, F. Duyser, Ann G. Bergman, Jasper van Oort, I. Tendolkar, A. Schene   +12 more
semanticscholar   +1 more source

Understanding Obstacles in Psychiatric Research: An Analysis of the Structure of Mood via Merleau-Ponty

Eidos. A Journal for Philosophy of Culture, 2020
It is no secret that the methodology within psychiatric research has been challenged to the point of a possible paradigm shift. After decades of failed attempts to determine biological markers for the mental illnesses classified by the Diagnostic ...
Raymond Cacciatore
doaj   +1 more source

Developing constructs for psychopathology research: Research domain criteria.

Journal of Abnormal Psychology, 2010
There exists a divide between findings from integrative neuroscience and clinical research focused on mechanisms of psychopathology. Specifically, a clear correspondence does not emerge between clusters of complex clinical symptoms and dysregulated neurobiological systems, with many apparent redundancies.
Charles A, Sanislow, Daniel S, Pine, Kevin J, Quinn, Michael J, Kozak, Marjorie A, Garvey, Robert K, Heinssen, Philip Sung-En, Wang, Bruce N, Cuthbert   +7 more
openaire   +3 more sources

Translational research in psychiatry: The Research Domain Criteria Project (RDoC)

Revista de Psiquiatría y Salud Mental (English Edition), 2019
Despite the consensus achieved in the homogenization of clinical criteria by categorical psychiatric classification systems (DEM and CIE), they are criticized for a lack of validity and inability to guide clinical treatment and research. In this review article we introduce the Research Domain Criteria (RDoC) framework as an alternative framework for ...
Vilar, Ana, Pérez-Sola, Víctor, Blasco, María Jesús, Pérez-Gallo, Elena, Ballester Coma, Laura, Batlle Vila, Santiago, Alonso, Jordi, Serrano-Blanco, Antoni, Forero, Carlos G.   +8 more
openaire   +5 more sources

Mapping disease course across the mood disorder spectrum through a Research Domain Criteria (RDoC) framework

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021
Background: The National Institute of Mental Health Research Domain Criteria (RDoC) initiative aims to establish a neurobiologically valid framework for classifying mental illness. Here, we examined whether the RDoC construct of Reward Learning and three
Alexis E. Whitton, Poornima Kumar, M. Treadway, Ashleigh V Rutherford, M. Ironside, Dan Foti, G. Fitzmaurice, F. Du, D. Pizzagalli   +8 more
semanticscholar   +1 more source

Potential Cross Talk between Autism Risk Genes and Neurovascular Molecules: A Pilot Study on Impact of Blood Brain Barrier Integrity

Cells, 2022
Autism Spectrum Disorder (ASD) is a common pediatric neurobiological disorder with up to 80% of genetic etiologies. Systems biology approaches may make it possible to test novel therapeutic strategies targeting molecular pathways to alleviate ASD ...
Rekha Jagadapillai, Xiaolu Qiu, Kshama Ojha, Zhu Li, Ayman El-Baz, Shipu Zou, Evelyne Gozal, Gregory N. Barnes   +7 more
doaj   +1 more source

The Research Domain Criteria: moving the goalposts to change the game [PDF]

British Journal of Psychiatry, 2014
SummaryThere is increasing concern that a reliance on the descriptive, syndrome-based diagnostic criteria of ICD and DSM is impeding progress in research. The USA's major funder of psychiatric research, the National Institute of Mental Health (NIMH), have stated their intention to ...
Joanne L, Doherty, Michael J, Owen
openaire   +2 more sources