Results 91 to 100 of about 67,932,399 (174)

The Role of Chronic Stress in Anxious Depression

Chronic Stress, 2017
Depression is a heterogeneous disease with many different subtypes. Patients with the anxious depression—a common subtype of major depression—are at an increased risk for treatment-resistance to standard antidepressants, with resultant increases in ...
Rachel A. Ross, Simmie L. Foster, Dawn F. Ionescu   +2 more
doaj   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Misunderstanding RDoC

, 2017
. Mental illness is fundamentally mental, by definition about psychological rather than biological phenomena, but biological phenomena play key roles in understanding, preventing, and treating mental illness.
Cindy M. Yee, Gregory A. Miller, Jessica I. Lake   +2 more
core   +1 more source

Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review

Early Intervention in Psychiatry, Volume 20, Issue 10, October 2026.
ABSTRACT Introduction Psychiatric biomarker research has traditionally been organized around diagnostic categories, but clinical heterogeneity, comorbidity and shared biological mechanisms across psychiatric conditions have increased interest in transdiagnostic approaches.
Katelyn Hummel, Luigi Boccuto, Sara M. Sarasua, Kendra Allison, Garrie B. Thompson III   +4 more
wiley   +1 more source

Challenges of Fear Conditioning Research in the Age of RDoC

, 2017
. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and
Jan Richter, Richter, Jan, Lonsdorf, Tina, Tina B. Lonsdorf   +3 more
core   +1 more source

A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive‐Compulsive Symptoms in Psychiatric Genetic Studies: A Cross‐Continental Study Within the Ancestral Population Network

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 6, Page 379-395, September 2026.
ABSTRACT This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive‐compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH
Ana M. Diaz‐Zuluaga, Jacey L. Anderberg, Ana M. Ramirez‐Diaz, Andrea Horvath Marques, Catherine E. Rast, Daniel Bustamante, Deborah Jonker, Johanna Valencia‐Echeverry, Joseph Kyebuzibwa, Josselyn S. Muñoz, Kristien van der Walt, Mauricio Castaño Ramirez, Olivia Wootton, Renee M. Frederick, Rocky E. Stroud II, Ruben Gur, Sang Jin Rhee, Shaili C. Jha, Stella Gichuru, Susan Service, Victor I. Reus, Akena Dickens, Carlos Lopez‐Jaramillo, Carrie E. Bearden, Dan J. Stein, Ezra S. Susser, James J. Crowley, Jonathan Flint, Kenneth S. Kendler, Lukoye Atwoli, Michele T. Pato, Nelson B. Freimer, Roel A. Ophoff, Yong Min Ahn, Loes Olde Loohuis, Eric A. Storch, Bizu Gelaye   +36 more
wiley   +1 more source

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

American Journal of Psychiatry, 2010
Self-archived author copy of a scholarly work originally published in American Journal of Psychiatry (2010), made available through Wesleyan University's digital collections.
Thomas, Insel, Bruce, Cuthbert, Marjorie, Garvey, Robert, Heinssen, Daniel S, Pine, Kevin, Quinn, Charles, Sanislow, Philip, Wang   +7 more
openaire   +3 more sources

Transdiagnostic assessment of mental disorders using the Research Domain Criteria (RDoC) approach: relationship to disease severity

, 2023
Traditionally, mental disorders have been identified based on specific symptoms and standardized diagnostic systems such as the DSM-5 and ICD-10. However, these symptom-based definitions may only partially represent neurobiological and behavioral ...
Förstner, Bernd Rainer (Dr.)
core   +1 more source

Distinct Neural Signatures Detected for ADHD Subtypes After Controlling for Micro-Movements in Resting State Functional Connectivity MRI Data

Frontiers in Systems Neuroscience, 2013
In recent years, there has been growing enthusiasm that functional MRI could achieve clinical utility for a broad range of neuropsychiatric disorders. However, several barriers remain.
Damien eFair, Joel T Nigg, Swathi eIyer, Deepti eBathula, Kathryn L Mills, Nico UF Dosenbach, Bradley L Schlaggar, Maarten eMennes, David eGutman, Saroja eBangaru, Jan K Buitelaar, Daniel P Dickstein, Adriana eDi Martino, David N Kennedy, Clare eKelly, Beatriz eLuna, Julie B Schweitzer, Katerina eVelanova, Yu-Feng eWang, Yu-Feng eWang, Stewart H Mostofsky, Stewart H Mostofsky, Francisco Xavier Castellanos, Francisco Xavier Castellanos, Michael P Milham, Michael P Milham   +25 more
doaj   +1 more source

Commentary: Towards an integrated understanding of general psychopathology—A commentary on Devine et al. (2026)

JCPP Advances, EarlyView.
Ling‐ling Wang, Yi Wang, Raymond C. K. Chan   +2 more
wiley   +1 more source