Results 81 to 90 of about 67,932,399 (174)

The research domain criteria (RDoC) project as a biological framework for research on mental disorders [PDF]

Eur Psychiatry
AbstractThe U.S. National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) offers a framework to facilitate clinical research for psychopathology. Unique features include an emphasis on transdiagnostic dimensions spanning normal and abnormal ranges of function, novel independent variables (mechanisms, not diagnoses), and the ...
Sanislow C.
europepmc   +3 more sources

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 8, Page 509-519, December 2026.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Situating psychophysiological science within the Research Domain Criteria (RDoC) framework

International Journal of Psychophysiology, 2015
The Research Domain Criteria (RDoC) reflects a paradigm shift in mental health research aimed at establishing a science of psychopathology that is grounded in neuroscience. In many ways, the RDoC approach to research has been utilized for decades by psychophysiologists who have leveraged a range of biological measures to study variability in ...
Greg, Hajcak, Hajcak, Greg, Patrick, Christopher J.   +2 more
openaire   +3 more sources

Toward a mental health research framework for natural and built environments [PDF]

E3S Web of Conferences
. Exposure to natural environments and biophilic design features has been associated with improvements in cognitive, affective, and physiological functioning.
Rosas Hernan, Hu Ming, Bernat Edward
doaj   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, Volume 59, Issue 11, Page 2375-2388, November 2026.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Research Domain Criteria and OCD

, 2017
This chapter discusses the Research Domain Criteria (RDoC) project, an initiative of the National Institutes of Mental Health (NIMH) of the United States to develop for research purposes new ways of classifying mental disorders based on dimensions of ...
Helen Blair Simpson, Eyal Kalanthroff, Gideon E. Anholt   +2 more
core   +1 more source

RDoC: Integrating genetics, imaging, & cognitive science to transform mental health diagnosis and treatment [PDF]

, 2015
Research Domain Criteria (RDoC): Integrating genetics, imaging, & cognitive science to transform mental health diagnosis and ...
Bruce N Cuthbert, Bruce N Cuthbert (5282680)   +1 more
core   +1 more source

Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene

Disease Models & Mechanisms, 2017
The research domain criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms.
Valentina Vengeliene, Anton Bespalov, Martin Roßmanith, Sandra Horschitz, Stefan Berger, Ana L. Relo, Hamid R. Noori, Peggy Schneider, Thomas Enkel, Dusan Bartsch, Miriam Schneider, Berthold Behl, Anita C. Hansson, Patrick Schloss, Rainer Spanagel   +14 more
doaj   +1 more source

Orbitofrontal and Medial Frontal Gray Matter Volumes Are Associated With Hyperactivity Traits in 2548 Nonclinical Adults

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In 2548 nonclinical adults, smaller orbitofrontal and medial frontal cortex gray matter volumes were associated with higher hyperactivity traits (r = −0.07 to −0.08). These small, robust effects, consistent with ENIGMA ADHD findings, suggest frontal structure–trait mapping extends to the nonclinical ADHD continuum.
Handityo Aulia Putra, Kaechang Park
wiley   +1 more source

Association of RDoC dimensions with post mortem brain transcriptional profiles in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Neuropsychiatric symptoms are common in people with Alzheimer's disease (AD) across all severity stages. Their heterogeneous presentation and variable temporal association with cognitive decline suggest shared and distinct biological ...
Weiqian Jiang, Jonathan Vogelgsang, Shu Dan, Peter Durning, Thomas H. McCoy, Sabina Berretta, Torsten Klengel   +6 more
doaj   +1 more source