Results 61 to 70 of about 52,409,792 (165)

Dimensional clinical phenotyping using post‐mortem brain donor medical records: post‐mortem RDoC profiling is associated with Alzheimer's disease neuropathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes.
Jonathan Vogelgsang, Shu Dan, Anna P. Lally, Michael Chatigny, Sangeetha Vempati, Joshua Abston, Peter T. Durning, Derek H. Oakley, Thomas H. McCoy, Torsten Klengel, Sabina Berretta   +10 more
doaj   +1 more source

Evolving Concepts of the Schizophrenia Spectrum: A Research Domain Criteria Perspective

Frontiers in Psychiatry, 2021
Several trends intersecting over the past two decades have generated increasing debate as to how the concepts of schizophrenia, the schizophrenia spectrum, and the psychotic disorders spectrum should be regarded.
Bruce N. Cuthbert, Sarah E. Morris
doaj   +1 more source

Editorial: Transdiagnostic approaches to child and adolescent mental health—Integrating development, dimensions, and mechanisms

JCPP Advances, EarlyView.
Abstract Co‐occurrence of child and adolescent neurodevelopmental and mental health conditions is the rule rather than the exception, yet translating this insight into shared frameworks and clinical practice remains challenging. In this Editorial, we are pleased to introduce the 26 papers included in the 2026 Special Issue of JCPP Advances.
Alessio Bellato, Stephen P. Becker, Catharina A. Hartman, Henrik Larsson, James J. Li, Samantha J. Lynch, Giorgia Michelini   +6 more
wiley   +1 more source

Enhancing post-traumatic stress disorder patient assessment: leveraging natural language processing for research of domain criteria identification using electronic medical records

BMC Medical Informatics and Decision Making
Background Extracting research of domain criteria (RDoC) from high-risk populations like those with post-traumatic stress disorder (PTSD) is crucial for positive mental health improvements and policy enhancements.
Oshin Miranda, Sophie Marie Kiehl, Xiguang Qi, M. Daniel Brannock, Thomas Kosten, Neal David Ryan, Levent Kirisci, Yanshan Wang, LiRong Wang   +8 more
doaj   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Research Domain Criteria (RDoC) Domains Across the Adult Lifespan: Confirmatory Factor Analysis and Age Differences in Latent RDoC Domains in a General Psychiatric Sample

The Research Domain Criteria (RDoC) framework offers a comprehensive system for conceptually guiding research on mental illness and health. The present study extends the work by Förstner et al.
Bernd R. Foerstner, Pauline Agnes Reusch, Frauke Waghals, Kristin Koller-Schlaud   +3 more
core   +5 more sources

A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive‐Compulsive Symptoms in Psychiatric Genetic Studies: A Cross‐Continental Study Within the Ancestral Population Network

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 6, Page 379-395, September 2026.
ABSTRACT This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive‐compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH
Ana M. Diaz‐Zuluaga, Jacey L. Anderberg, Ana M. Ramirez‐Diaz, Andrea Horvath Marques, Catherine E. Rast, Daniel Bustamante, Deborah Jonker, Johanna Valencia‐Echeverry, Joseph Kyebuzibwa, Josselyn S. Muñoz, Kristien van der Walt, Mauricio Castaño Ramirez, Olivia Wootton, Renee M. Frederick, Rocky E. Stroud II, Ruben Gur, Sang Jin Rhee, Shaili C. Jha, Stella Gichuru, Susan Service, Victor I. Reus, Akena Dickens, Carlos Lopez‐Jaramillo, Carrie E. Bearden, Dan J. Stein, Ezra S. Susser, James J. Crowley, Jonathan Flint, Kenneth S. Kendler, Lukoye Atwoli, Michele T. Pato, Nelson B. Freimer, Roel A. Ophoff, Yong Min Ahn, Loes Olde Loohuis, Eric A. Storch, Bizu Gelaye   +36 more
wiley   +1 more source

Transdiagnostic assessment of mental disorders using the Research Domain Criteria (RDoC) approach: relationship to disease severity

, 2023
Traditionally, mental disorders have been identified based on specific symptoms and standardized diagnostic systems such as the DSM-5 and ICD-10. However, these symptom-based definitions may only partially represent neurobiological and behavioral ...
Förstner, Bernd Rainer (Dr.)
core   +1 more source

Can circadian rhythm predict changes in neurocognitive functioning in bipolar disorder: protocol of a 12-month longitudinal cohort study based on research domain criteria

Annals of Medicine, 2023
Introduction: Bipolar disorder (BD) is a prevalent and disabling mental disorder characterized by disrupted circadian rhythms and impaired neurocognitive features, both of which fall under the major domains of Research Domain Criteria (RDoC).
Huirong Luo, Xueqian Wang, Yinlin Zhang, Junyao Li, Renqin Hu, Zheng Zhang, Qian Liao, Xiaoxin Zhou, Wei Deng, Jian Yang, Qinghua Luo   +10 more
doaj   +1 more source

Directionality of longitudinal associations between frontostriatal structural connectivity and depressive symptoms in adolescent girls

Journal of Child Psychology and Psychiatry, Volume 67, Issue 8, Page 1361-1370, August 2026.
Background Individual differences in the structure and function of the frontostriatal reward network have been related to depression. However, there is a strong need for prospective, longitudinal studies aiming to understand the role of frontostriatal networks in depression in a developmental context.
Marjolein E.A. Barendse, Chris J. Machle, Rogier Kievit, Jennifer H. Pfeifer   +3 more
wiley   +1 more source