Results 41 to 50 of about 4,543 (156)

Operationalizing NIMH Research Domain Criteria (RDoC) in naturalistic clinical settings [PDF]

Bulletin of the Menninger Clinic, 2016
Recently, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) initiative to address two major challenges facing the field of psychiatry: (1) the lack of new effective personalized treatments for psychiatric disorders, and (2) the limitations associated with categorically defined psychiatric disorders.
Sharp, C, Fowler, C, Salas, R, Nielsen, D, Allen, J, Oldham, J, Kosten, T, Matthew, S, Madan, A, Frueh, BC, Fonagy, P   +10 more
openaire   +3 more sources

The biological classification of mental disorders (BeCOME) study: a protocol for an observational deep-phenotyping study for the identification of biological subtypes

BMC Psychiatry, 2020
Background A major research finding in the field of Biological Psychiatry is that symptom-based categories of mental disorders map poorly onto dysfunctions in brain circuits or neurobiological pathways.
Tanja M. Brückl, Victor I. Spoormaker, Philipp G. Sämann, Anna-Katharine Brem, Lara Henco, Darina Czamara, Immanuel Elbau, Norma C. Grandi, Lee Jollans, Anne Kühnel, Laura Leuchs, Dorothee Pöhlchen, Maximilian Schneider, Alina Tontsch, Martin E. Keck, Leonhard Schilbach, Michael Czisch, Susanne Lucae, Angelika Erhardt, Elisabeth B. Binder   +19 more
doaj   +1 more source

Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation [PDF]

Biological Psychiatry, 2016
The value of common polymorphisms in guiding clinical psychiatry is limited by the complex polygenic architecture of psychiatric disorders. Common polymorphisms have too small an effect on risk for psychiatric disorders as defined by clinical phenomenology to guide clinical practice. To identify polymorphic effects that are large and reliable enough to
Charles E, Glatt, Francis S, Lee
openaire   +2 more sources

The Research Domain Criteria framework: transitioning from dimensional systems to integrating neuroscience and psychopathology

Psychiatry and Clinical Psychopharmacology, 2017
Although recent research in neuroscience and genetics is providing new insights into the etiology of psychiatric disorders, progress in treatment development has been hindered by reliance on diagnostic categories that are based primarily on presenting ...
Samet Kose, Mesut Cetin
doaj   +1 more source

Integrating DSM/ICD, Research Domain Criteria, and Descriptive Psychopathology in Teaching and Practice of Psychiatry

Frontiers in Psychiatry, 2018
Background: Some believe that Psychiatry relies solely on the Diagnostic and Statistical Manual of Mental Disorders (DSM). Some are not aware of the effort initiated by the Research Domain Criteria (RDoC) to propel the field to a new era of Medicine ...
Dimy Fluyau
doaj   +1 more source

Integrating NIMH Research Domain Criteria (RDoC) into PTSD Research

, 2017
Three and a half decades of research on posttraumatic stress disorder (PTSD) has produced substantial knowledge on the pathobiology of this frequent and debilitating disease. However, despite all research efforts, so far no drug that has specifically targeted PTSD core symptoms progressed to clinical use.
Schmidt, U., Vermetten, E.
openaire   +3 more sources

O projeto Research Domain Criteria e o abandono da tradição psicopatológica

Revista Latinoamericana de Psicopatologia Fundamental, 2014
O artigo explora os pressupostos epistemológicos do Research Domain Criteria (RDoC) - projeto de investigação empírica dos transtornos mentais, dentro de uma plataforma biológica - promovido pelo National Institute of Mental Health (NIMH).
Rafaela Zorzanelli, Paulo Dalgalarrondo, Cláudio E. M. Banzato   +2 more
doaj   +1 more source

Using the Research Domain Criteria as a framework to integrate psychophysiological findings into stress management and psychotherapy interventions

Frontiers in Neuroergonomics, 2023
Research on the psychophysiology of stress is expanding rapidly, but the field lacks a clear integrative framework to help translate research findings into empirically supported stress interventions.
Patrick R. Steffen
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

A data-driven latent variable approach to validating the research domain criteria framework

Nature Communications
Despite the widespread use of the Research Domain Criteria (RDoC) framework in psychiatry and neuroscience, recent studies suggest that the RDoC is insufficiently specific or excessively broad relative to the underlying brain circuitry it seeks to ...
S. K. L. Quah, B. Jo, C. Geniesse, L. Q. Uddin, J. A. Mumford, D. M. Barch, D. A. Fair, I. H. Gotlib, R. A. Poldrack, M. Saggar   +9 more
doaj   +1 more source