Results 111 to 120 of about 5,045,747 (304)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Ethics outside, within or beyond OR models [PDF]
Since ethical concerns are calling for more attention within Operational Research, we present three approaches to combine Operational Research models with ethics.
Luk N. Van Wassenhove, Marc Le Menestrel
core
Research Ethics and Fieldwork at New Consumption Communities [PDF]
, 2005 It is hard to deny that marketing practice has changed considerably during recent years. This is reflected in its increased focus on customisation, coproduction and interactive marketing, much of which has been enabled by new information technologies ...
Bekin, C
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
AGRO-ETHICS: EXTENSION, RESEARCH, AND TEACHING [PDF]
Teaching/Communication/Extension/Profession,
Johnson, Glenn L.
core +1 more source
Transformative Ethics and Moving Toward “Greatness” – Problems and Realities [PDF]
, 2019 The purpose of this paper is to emphasize the role of Transformative Ethics as leaders and organizations move toward the achievement of greatness. It is a conceptual paper that explains the key importance of the pursuit of greatness and the role of ...
Ali Habib Al Lawati, Hawaraa +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A review of research ethics in internet-based research [PDF]
, 2012 Internet-based research methods can include; on-line surveys, web page content analysis, videoconferencing for on-line focus groups and/ or interviews, analysis of ‘e’ conversations through social networking sites, email, chat rooms, discussion boards ...
Convery, Ian, Cox, Diane
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source