Results 191 to 200 of about 53,502,383 (247)

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Convergences and Gaps between Environmental Ethics, Climate Ethics, and Research Ethics: A Scoping Review. [PDF]

Sci Eng Ethics
Bourban M, Lenzi D, Sørensen MP, Fishberg R, Mehlich J, Fischbach F, Molina JL, Poague KIHM, Csábi A, Heffernan R, Hastings R, Rességuier A.   +11 more
europepmc   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Strengthening Research Ethics Capacity in West Africa, 2015-2024. [PDF]

J Empir Res Hum Res Ethics
Ferguson K, Adebamowo C, Adejumo AO, Ogundiran T, Aliyu MH, Gordon EJ, Iliyasu Z, Agulanna C, Adamu SU, Adeyemo O, Ezugwu EC, Adeyemo SA, Caplan AL, Ogedegbe O, Moon TD, Heitman E, Taylor JC, Bari I, Hyder AA, Ndebele P, Doumbia S, Njie-Carr VPS, Sey-Sawo J, Silverman H, Usuf E, Senghore T, de Pina Araújo IIM, Laar AK, Ezeome ER.   +28 more
europepmc   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

"Who are you going to call?:" Research ethics consultation directors' perspectives on barriers and facilitators. [PDF]

J Clin Transl Sci
Miner SA, McCormick JB, Taylor HA.
europepmc   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Ethical Guidance for Investigational Implantable Neural Device Studies: Recommendations for Researchers and Research Ethics Committees. [PDF]

Neuromodulation
van Stuijvenberg OC, Bassil KC, de Vos CC, Geleijnse G, Noordmans HJ, Broekman MLD, van der Graaf R, Bertens RM, Lázaro-Muñoz G, Jongsma KR.   +9 more
europepmc   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

A Scoping Review of Empirical Research on Research Ethics Board Membership and Expertise. [PDF]

J Empir Res Hum Res Ethics
Tumilty E, Young J, James R, Serpico K, Johnson A, Anderson EE.   +5 more
europepmc   +1 more source