Results 71 to 80 of about 5,045,747 (304)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Symposium on Revenue Transparency, Resource Development, and the Challenge of Corruption [PDF]

Revenue transparency and corruption in the mining industry have long been topics of national and international conversation. Mining plays an important role in the Canadian economy, contributing billions to Canada’s GDP.
Canadian Business Ethics Research Network (CBERN)
core  

The ethics of genetic research on intelligence [PDF]

, 2000
Should research on the possible genetic components of human intelligence be carried out? I first try to provide some general guidelines as to whether any particular piece of research should be undertaken and then consider the specific example of the ...
Reiss, Michael
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Bioethics and transdisciplinarity as bridges for dialogue between health sciences and social and/or human sciences in the context of the ethics evaluation of research

Salud Colectiva, 2022
Volnei Garrafa
doaj   +1 more source

How Should I Care: Research Ethics and Its Tensions in Participatory Action Research

Dutch Journal of Applied Linguistics
In Shepperd and Dalderop (forthcoming)’s viewpoint Why should I care? Research ethics in the field of adult L2 Literacy, the authors make three important assertions regarding research ethics with so called vulnerable participants.
Amber Bartlett
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The new International Health Regulations and the federalism dilemma. [PDF]

PLoS Medicine, 2006
Kumanan Wilson, Christopher McDougall, Ross Upshur, Joint Centre for Bioethics SARS Global Health Ethics Research Group   +3 more
doaj   +1 more source

The Underrepresentation of Women in Prestigious Ethics Journals [PDF]

, 2017
It has been widely reported that women are underrepresented in academic philosophy as faculty and students. This article investigates whether this representation may also occur in the domain of journal article publishing.
Dalecki, Maggie, Deveaux, Monique, Krishnamurthy, Meena, Liao, Shen‐yi   +3 more
core   +1 more source