Results 121 to 130 of about 841,358 (341)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Conhecimento e envolvimento de graduandos em fisioterapia acerca dos preceitos éticos da experimentação animal

Revista Bioética
O artigo analisa em amostra de universitários do curso de fisioterapia indicadores éticos ao uso de animais na pesquisa e no ensino e o nível de conhecimento e interesse dos alunos sobre o tema ética animal.
Igor Fagioli Bordello Masson, Cristiano Schiavinato Baldan, Vanessa Reimberg Ramalho, Ivaldo Esteves Junior, Daniela Fagioli Masson, Beatriz de Oliveira Peixoto, Cassio Marcos Vilicev, Thiago Saikali Farcic   +7 more
doaj  

Submission to Healthcare Ethics Committees in Portugal: Our Experience

Acta Médica Portuguesa
N/a.
Daniela Ribeiro, Carolina Sotana, Goranka Petriček, Joana Azeredo, Bruno Heleno   +4 more
doaj   +1 more source

A Clash of Paradigms? Ethnography and Ethics Approval

SAGE Open, 2017
Obtaining ethics approval from university ethics committees is an important part of the research process in Australia and internationally. However, for researchers engaging in ethnographic work, obtaining ethics approval can (re)present significant ...
Virginia Mapedzahama, Tinashe Dune
doaj   +1 more source

Physical activity counselling in Ireland: a survey of doctors’ knowledge, attitudes and self-reported practice

BMJ Open Sport & Exercise Medicine, 2019
Objective Physical activity (PA) counselling has been shown to raise awareness of the importance of PA and to increase the rate of PA engagement among patients.
Lucia Prihodova, Sarah O'Brien, Mairéad Heffron, Peter Wright   +3 more
doaj   +1 more source

Extent of Non-Publication in Cohorts of Studies Approved by Research Ethics Committees or Included in Trial Registries

PLoS ONE, 2014
Background The synthesis of published research in systematic reviews is essential when providing evidence to inform clinical and health policy decision-making.
C. Schmucker, Lisa K Schell, Susan Portalupi, Patrick Oeller, Laura Cabrera, D. Bassler, G. Schwarzer, R. Scherer, G. Antes, E. von Elm, J. Meerpohl   +10 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ethics committees and the changed clinical research environment in India in 2016: A perspective!

Perspectives in Clinical Research, 2017
Introduction: Institutional and Independent Ethics Committees (ECs) have as their primary mission the protection of human research subjects. The Central Drugs Standard Control Organization has in the period 2013–2016 introduced several new regulations ...
Sanish Davis, Poonam Sule, Murtuza Bughediwala, Vrunda Pandya, Shilpi Sinha   +4 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Research Ethics Committees (RECs) and the Creaking Piers of Peer Review [PDF]

[No abstract][No keywords]
John Holmwood
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