Results 121 to 130 of about 194,883 (245)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
RESEARCH ETHICS COMMITTEES (RECs) AND MONITORING OF BIOMEDICAL RESEARCH IN PAKISTAN
Khyber Medical University Journal, 2013 Global health is facing enormous challenges and medical research is the only way to cope with these challenges. Worldwide, extensive clinical research is being conducted in all fields of medicineto resolve the health related issues through best available
Akhtar Sherin
doaj
The Challenges of Big Data for Research Ethics Committees: A Qualitative Swiss Study. [PDF]
J Empir Res Hum Res Ethics, 2022 Ferretti A +4 more
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Accreditation of research ethics committees in Paraguay: An ethical imperative. [PDF]
Rev Bioet Derecho Perspect Bioet, 2023 García CRC, Bianchini AD.
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Ethical Guidance for Investigational Implantable Neural Device Studies: Recommendations for Researchers and Research Ethics Committees. [PDF]
Neuromodulationvan Stuijvenberg OC +9 more
europepmc +1 more source
Key ethical issues encountered during COVID-19 research: a thematic analysis of perspectives from South African research ethics committees. [PDF]
BMC Med Ethics, 2023 Burgess T, Rennie S, Moodley K.
europepmc +1 more source