Results 121 to 130 of about 200,706 (288)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Ethics in a scientific approach: the importance of the biostatistician in research ethics committees

open access: yes, 2008
In medical practice and research it is necessary to consider the rights of the researcher or physician and of the subject or patient, to conform to scientific standards and to examine the appropriateness with respect to laws and moral values.

core   +1 more source

Navigating the Process of Ethical Approval: A methodological note

open access: yesGrounded Theory Review: An International Journal, 2010
Classic grounded theory (CGT) methodology is a general methodology whereby the researcher aims to develop an emergent conceptual theory from empirical data collected by the researcher during the research study.
Eileen Carey, RNID, BSc. (hons), MSc.
doaj   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Research, Ethics Committees and Legal Issues

open access: yes, 2003
Who should be publicly authorized to consider legal issues in research? This paper argues that public policy should authorise ethics committees to consider legal issues about their own actions regarding particular research proposals; and that it should ...
Moore, Andrew
core  

Impact of recent legislative bills regarding clinical research on Italian ethics committee activity.

open access: yes, 2008
: Aims and background: The present work assessed the impact of two decrees on ethics committees in Italy, aimed at bringing the national laws on the conduct of clinical trials into line with the rest of the EC, and regulating and facilitating not-for ...
POLI D   +10 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Academicians' Views on Research and the Ethics of Publication

open access: yes, 2016
WOS: 000439229100004This research intends to identify the inappropriate ethical behaviors of academic personnel mostly on research and the ethics of publication as determined by the Turkish Academy of Sciences (Turkiye Bilimler Akademisi [TUBA]) and to ...
Özcan, Müesser, Balcı, Yasemin
core   +1 more source

ETHICS COMMITTEES AND EXTERNALLY-SPONSORED RESEARCH IN IRAN (2002-2003)

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2006
Background: Globally, there have been considerable debates on the ethical conduct and review of collaborative international research. One of the great challenges is to conduct clinical trials in developing countries as Externally-Sponsored Researches ...
B Larijani,   +9 more
doaj  

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