Results 61 to 70 of about 484,149 (288)
Getting Beyond Form Filling: The Role of Institutional Governance in Human Research Ethics [PDF]
, 2018 It has become almost a truism to describe the interaction between research ethics committees and researchers as being marred by distrust and conflict.
Allen, Gary
core
Failure to apply for ethical approval for health studies in low-income countries [PDF]
, 2015 Too many occasions researchers conduct public health and/or epidemiological studies in low-income countries without the appropriate in-country ethical approval. This article reflects on some of the underlying reasons for not applying for ethical approval.
Simkhada, Padam, van Teijlingen, Edwin
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Charting regulatory stewardship in health research:Making the invisible visible? [PDF]
, 2018 : This article analyses a hitherto largely obscured feature of regulatory environments in health research; namely, the role of regulatory stewardship.
AGOMONI GANGULI-MITRA +9 more
core +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ethics approval: responsibilities of journal editors, authors and research ethics committees
The Pan African Medical Journal, 2017 Meaningful progress of medicine depends on research that must ultimately involve human subjects. Obtaining ethical approval therefore, especially in medical sciences, should be a moral reflex for researchers.
Luchuo Engelbert Bain
doaj +1 more source
BMC Medical Ethics, 2005 Background Clinical trials throughout the world must be evaluated by research ethics committees. No one has yet attempted to clearly quantify at the national level the activity of ethics committees and describe the characteristics of the protocols ...
Lhéritier Véronique +2 more
doaj +1 more source
Ethical challenges in cross-cultural field research: a comparative study of UK and Ghana [PDF]
, 2015 YesResearch ethics review by ethics committees has grown in importance since the end of the Nuremberg trials in 1949. However, ethics committees have come under increasing criticisms either for been ‘toothless or too fierce’ (Fistein & Quilligan, 2012 ...
Adu-Gyamfi, Jones
core +1 more source
Expert perspectives on ethics review of international data-intensive research:Working towards mutual recognition [PDF]
, 2017 Life sciences research is increasingly international and data-intensive. Researchers work in multi-jurisdictional teams or formally established research consortia to exchange data and conduct research using computation of multiple sources and volumes of
Dove, Edward S., Garattini, Chiara
core +3 more sources