Results 91 to 100 of about 57,215,976 (259)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Navigating bibliometric indicators in university rankings: a conceptual framework for strategic research management

open access: yesFrontiers in Research Metrics and Analytics
The increasing prominence of global university rankings has fundamentally transformed the strategic landscape of higher education institutions worldwide.
Wael Alkattan   +4 more
doaj   +1 more source

Architecture Enabling Adaptation of Data Integration Processes for a Research Information System

open access: yesFoundations of Computing and Decision Sciences, 2018
Today, many efforts have been made to implement information systems for supporting research evaluation activities. To produce a good framework for research evaluation, the selection of appropriate measures is important.
Solodovnikova Darja   +2 more
doaj   +1 more source

How are Educational Researchers Interacting with End-users to Increase Impact?

open access: yesEngaged Scholar Journal, 2018
   There has been increased interest in how researchers might collaborate with end users to increase the impact of their work. In Canada, efforts to extend research impact beyond academia are called knowledge mobilization (KMb).
Amanda Cooper
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Identifying the intended user(s) and use(s) of an evaluation [PDF]

open access: yes, 2012
French version available in IDRC Digital Library: Détermination des utilisateurs et des utilisations prévus d’une évaluationThe decision to evaluate should be strategic and not rote.
IDRC. Evaluation Unit
core  

The Italian Research Assessment Exercises

open access: yesItalian Political Science, 2018
Italian universities have so far experienced three assessment exercises (2001-3, 2004-10 and 2011-14). The fiscal law approved in December 2016 dictates that from now onwards the reference periods will be quinquennial, reducing the discretionary power so
Daniele Checchi
doaj  

Independent researchers in east Asian surgical research: structural barriers and potential policy pathways

open access: yesFrontiers in Research Metrics and Analytics
East Asia is now a major center of surgical innovation. Its leading institutions have contributed to clinical care, technology adoption, and international trials.
Cheng Che, Xu Gong
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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