Results 111 to 120 of about 4,970,902 (314)
African doctoral dissertation research fellowship (ADDRF) program : evaluation report [PDF]
, 2013 The ADDRF Program was initiated in 2008 by the African Population and Health Research Center (APHRC) in partnership with the International Development Research Center (IDRC).
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Evaluating research proposals [PDF]
Nature, 1995 F C, van den Beemt, A F, van Raan
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Corrigendum: Corrigendum: Evaluative altmetrics: is there evidence for its application to research evaluation? [PDF]
Front Res Metr Anal, 2023 Arroyo-Machado W, Torres-Salinas D.
europepmc +1 more source
Wheat Seed and Agricultural Programming in Afghanistan: Its Potential to Impact on Livelihoods
, 2004 This report outlines the results of one of three combined “special studies,” conducted under the auspices of the European Commission-funded Afghanistan Research and Evaluation Unit (AREU) livelihoods monitoring research project.
Coke, Alexia +1 more
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SWELL Action 3 Evaluation [PDF]
, 2005 This report details the findings of research undertaken by the Employment Research Institute, Napier University, Edinburgh as part the evaluation of the Scottish Workforce Empowerment for Lifelong Learning (SWELL) project.
Lindsay, Colin, McQuaid, Ronald
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source