Results 251 to 260 of about 4,970,902 (314)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
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Research to Action: An Evaluation
Nursing Leadership, 2012The evaluation of the Research to Action project was conducted using an Outcome Mapping (OM) methodology (Earl et al. 2001) with a mixed-methods, repeat survey (before/after) study design. This design uses concurrent measurement of process and outcome indicators at baseline and follow-up.
Gail Tomblin, Murphy +4 more
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Nursing Administration Quarterly, 1996
Evaluation is often described as different from research. In this article, common myths about evaluation are discussed as well as reasons these myths no longer fit with current understanding of evaluation research. Issues associated with the conduct of evaluation studies are described, with recommendations made for maximizing the rigor of designs ...
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Evaluation is often described as different from research. In this article, common myths about evaluation are discussed as well as reasons these myths no longer fit with current understanding of evaluation research. Issues associated with the conduct of evaluation studies are described, with recommendations made for maximizing the rigor of designs ...
openaire +2 more sources
The Evaluator/Researcher as Person vs. The Person as Evaluator/Researcher
Educational Researcher, 1988This paper outlines two views of what it means to be a person and then discusses the relationship of these views to the issues of relativism and research methods. The contention is that relativism is an inevitable consequence of our interpretive or significance-making mode of being in the world.
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Research on research evaluation
Social Epistemology, 1996(1996). Research on research evaluation. Social Epistemology: Vol. 10, Economic Metaphors in Science Studies, pp. 209-250.
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