Results 131 to 140 of about 30,282,823 (310)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conservation practitioners’ and researchers’ needs for bridging the knowledge–action gap

Frontiers in Conservation Science
In the field of biodiversity conservation, there is a growing need for research to translate to real-world impacts. Currently there exists a gap between research outcomes and on the ground action, commonly referred to as the knowledge-action gap ...
Alexandra N. Sabo, Oded Berger-Tal, Daniel T. Blumstein, Alison L. Greggor, John P. Swaddle   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Scoping good papers for organizations' sustainability in management and engineering research

Frontiers in Sustainability, 2023
Tomohiko Sakao, Cheryl Desha, Ilija Djekic, Claudio Favi, Olawale Emmanuel Olayide, Magdalena Ziolo, Jussi Kantola, María Jesús Muñoz-Torres, Ubiratã Tortato, Jordi Segalas, Krzysztof Urbaniec, Ernesto D. R. Santibanez-González, Maria Francesca Renzi, Stefan Seuring, Rodrigo Lozano   +14 more
doaj   +1 more source

An Environmental Scan of Bibliometrics and Research Impact Open Instructional Trends at Canadian Academic Research Libraries

Canadian Journal of Academic Librarianship
While bibliometrics have been used for years in academia, recent conversations into their responsible use have driven a need for greater understanding of bibliometrics and research impact within the academic community.
Megan Palmer, Laura Bredahl, Kari Weaver
doaj   +1 more source

Research impact in randomized controlled trials of diabetes: an altmetric approach. [PDF]

J Diabetes Metab Disord, 2023
Sedghi S, Abouhamzeh K, Dokhani F, Delavari S, Soltani A, Soleimanpour S, Nemati-Anaraki L, Aletaha A.   +7 more
europepmc   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Comparing traditional bibliometrics and Altmetric assessments of research impact in respiratory disease. [PDF]

ERJ Open Res, 2023
Dutt E, Hurst JR.
europepmc   +1 more source