Results 71 to 80 of about 131,206,127 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
BiomimeticsBiological thin-sheet systems, including leaves, insect wings, and flowering organs, achieve adaptive deformation through distributed compliance, segmentation, curvature, and controlled opening.
Tarek H. Mokhtar +2 more
doaj +1 more source
A Taxonomy for Enterprise Architecture Analysis Research
Proceedings of the 21st International Conference on Enterprise Information Systems, 2019 Enterprise Architecture (EA) practitioners and researchers have put a lot of effort into formalizing EA model representation by defining sophisticated frameworks and meta-models. Because EA modelling is a cost and time-consuming effort, it is reasonable for organizations to expect to extract value from EA models in return. Due to the plethora of models,
Amanda Oliveira Barbosa +3 more
openaire +4 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Impact of Interactive Classroom Interior Design on Students’ Perceived Well-being: A Case Study of Egyptian Language Schools, Cairo. [PDF]
JES: Journal of Engineering SciencesThis study investigates the impact of interactive classroom interior design on students' perceived physical, cognitive, and social well-being through an integrated architectural evaluation framework.
Yara Farrag +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Researching Architectural Research
, 2016 Avigail Sachs, UT Knoxville professor and CED alumna, in conversation with RM1000 editor Jennifer Gaugler.
Sachs, Avigail, Gaugler, Jennifer
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Open Research EuropeSituated in the Westfjords of Iceland, Ísafjörður is an important place in the history of cod fisheries. This paper discusses the methodology of a weeklong workshop on the intricate connections between urban development and the Atlantic cod (Gadus morhua)
André Tavares +5 more
doaj +1 more source
Architecture & Research: A Possible Structure
, 2011 Revista Lusófona de Arquitectura e ...
openaire +3 more sources