Results 181 to 190 of about 11,395,926 (309)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Assessment of Problems Associated with Landfilling or Land Application of Pesticide Waste and Feasibility of Cleanup by Microbial Degradation

, 1990
Made available in DSpace on 2007-09-08T22:22:46Z (GMT). No. of bitstreams: 1 RR-E53b.PDF: 4627601 bytes, checksum: 26366b40a72a64d0b4056da87fc9b1b7 (MD5) Previous issue date: 1990Prepared for the Hazardous Waste Research and Information Center ...
Felsot, Allan, Case, Laurie, Dzantor, E. Kudjo   +2 more
core  

The National Institutes of Health's Biomedical Translational Research Information System (BTRIS): design, contents, functionality and experience to date. [PDF]

J Biomed Inform, 2014
Cimino JJ, Ayres EJ, Remennik L, Rath S, Freedman R, Beri A, Chen Y, Huser V.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Patterns of information use and exchange: case studies of researchers in the life sciences

, 2009
Scientific advances, the availability of powerful new information and communications technologies, and new policies governing research funding have brought major changes for life science researchers. Together these developments have significantly altered
Research Information Network, Institute for the Study of Science, Technology and Innovation, British Library, Digital Curation Centre   +3 more
core  

Profiling the molecular and clinical landscape of glioblastoma utilizing the Oncology Research Information Exchange Network brain cancer database. [PDF]

Neurooncol Adv
Demetriou AN, Chow F, Craig DW, Webb MG, Ormond DR, Battiste J, Chakravarti A, Colman H, Villano JL, Schneider BP, Liu JKC, Churchman ML, Zada G.   +12 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Research applications in information and library studies seminar (RAILS)

, 2005
This is the edited proceedings of a Seminar held at the Queensland University of Technology Brisbane, September 20th, 2004.\ud \ud Individual contributions were as follows: \ud \ud Seminar introduction: Applying research to practice in information and ...
Middleton, Michael R.
core  

Djeen (Database for Joomla!'s Extensible Engine): a research information management system for flexible multi-technology project administration. [PDF]

BMC Res Notes, 2013
Stahl O, Duvergey H, Guille A, Blondin F, Vecchio AD, Finetti P, Granjeaud S, Vigy O, Bidaut G.   +8 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source