Results 171 to 180 of about 11,395,926 (309)

Research to inform the consent-to-research process [PDF]

Intensive Care Medicine, 2013
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Characteristics of exercise and rehabilitation intervention clinical trials registered with Clinical Research Information Service: a review. [PDF]

J Exerc Rehabil
Lim JH, Kim BG, Choi AY.
europepmc   +1 more source

Extension of the primary care research object model (PCROM) as clinical research information model (CRIM) for the "learning healthcare system". [PDF]

BMC Med Inform Decis Mak, 2014
Kuchinke W, Karakoyun T, Ohmann C, Arvanitis TN, Taweel A, Delaney BC, Speedie SM.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN). [PDF]

Cancer Epidemiol Biomarkers Prev
Coghill AE, Van Bibber N, Baiocchi RA, Arnold SM, Riedlinger G, Schneider BP, Zhang Y, Suneja G, Gomez Fontela M, Abate-Daga D, Teer JK.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Our Changing Planet: The FY 1995 U.S. Global Change Research Program

, 1994
The U.S. GLOBAL CHANGE RESEARCH PROGRAM (USGCRP) supports activities that provide information and policy-relevant understanding about the coupling of human activities and the environment across a broad range of issues, perspectives, and interactions ...
U.S. Global Change Research Information Office
core  

Practices and Barriers in Developing and Disseminating Plain-Language Resources Reporting Medical Research Information: A Scoping Review. [PDF]

Patient
Pal A, Arnet I, Elger BS, Wangmo T.
europepmc   +1 more source

Finding research information on the web: how to make the most of Google and other free search tools. [PDF]

Sci Prog, 2013
Blakeman K.
europepmc   +1 more source