Results 41 to 50 of about 2,590,478 (309)

Enabling the Reuse of Long-Term Marine Biological Observations in Essential Variables Frameworks Through a Practical Approach

Frontiers in Marine Science, 2021
Essential Biodiversity Variables (EBVs) and Biological and Ecosystem Essential Ocean Variables (BioEco EOVs) are two cooperative conceptual frameworks which help harmonize and process multi-source marine biodiversity observations into robust indexes, in ...
Martina Zilioli, Caterina Bergami, Paola Carrara, Cristiano Fugazza, Alessandro Oggioni, Alessandra Pugnetti, Paolo Tagliolato Acquaviva d’Aragona   +6 more
doaj   +1 more source

Rethinking (Research) Infrastructures

, 2021
PDF presentation of the PhD Seminar given on 21.09 ...
openaire   +1 more source

Evaluation Factors for Multi-Stakeholder Broadband Visual Communication Projects [PDF]

, 2002
This paper presents a summary of multifaceted evaluation factors that we have identified through our research with Broadband Visual Communication (BVC) projects involving multiple stakeholders.
Barfurth, Marion A., Brooks, Martin, Emond, Bruno, Singer, Janice, Spence, John, Vinson, Norman   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Research infrastructures for Europe's scientists [PDF]

EMBO reports, 2011
The EU is currently negotiating its next budget for research. It needs to invest more in research infrastructures if it wants to become a global leader in research and improve its competitiveness.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Towards a service-oriented e-infrastructure for multidisciplinary environmental research [PDF]

, 2010
Research e-infrastructures are considered to have generic and thematic parts. The generic part provids high-speed networks, grid (large-scale distributed computing) and database systems (digital repositories and data transfer systems) applicable to all ...
Athanasiadis, I.N., Beulens, A.J.M., Kassahun, A., Krause, A., Makowski, M., Rizzoli, A.E., Scholten, H.   +6 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

25 Years of Molecular Biology Databases: A Study of Proliferation, Impact, and Maintenance

Frontiers in Research Metrics and Analytics, 2018
Online resources enable unfettered access to and analysis of scientific data and are considered crucial for the advancement of modern science. Despite the clear power of online data resources, including web-available databases, proliferation can be ...
Heidi J. Imker
doaj   +1 more source

Cost assessment model for sustainable operation and maintenance of large public research infrastructures

Journal of Asian Architecture and Building Engineering, 2022
For efficient operation and maintenance of Large Public Research Infrastructures (LPRIs) built with expensive equipment and operating engineers, reasonable budget needs to be allocated.
Bumjin Han, Seunghyun Son, Sunkuk Kim
doaj   +1 more source