Results 71 to 80 of about 873,999 (316)
Environmental Research: HealthAssessing the health impacts of climate stressors is challenging due to the inherently interdisciplinary nature of the effort and the complexity of data, methods, and software involved.
Emma L Gause +12 more
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SHS Web of Conferences, 2016 In this work the results of the research on Digital Humanities (DH) as interdisciplinary field of researches are presented, the main digitalization directions of the humanities in the modern world are defined.
Mozhaeva Galina, Renha Polina Mozhaeva
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
British Journal of Pharmacy, 2019 Development of age appropriate medicines for children is one of the major challenge of our century. Historically, research of new paediatric drugs has been neglected due to poor industrial interest and limited public and private investments. The ID-EPTRI
Donato Bonifazi +7 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A Note on Infrastructure Quality in South Africa [PDF]
The emphasis, both in research and in policy making, seems to be on more infrastructure, rather than better infrastructure. This research note aims to critically analyse the lack of quality indicators in infrastructure empirics and to redirect attention ...
Johan Fourie
core
Everything, everywhere, and all at once: A blueprint for supra‐organization of core facilities
FASEB BioAdvancesCore facilities are crucial for cutting‐edge scientific research in academic institutions, yet they place a significant financial burden on budgets. The viability of these facilities can be improved through cross‐institutional collaborations, although ...
Tsiona Elkayam Cohen, Robert Fluhr
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Research infrastructures as a key optimizer of european research [PDF]
Europhysics News, 2019 The European Strategy Forum on Research Infrastructures (ESFRI) has been created to advise the Competitiveness Council of the European Union on the needs and opportunities to build a strong Research Infrastructure (RI) system, covering all domains of research, providing the most advanced tools that cannot be realized at national level, and that must be
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Education and Training for Research Infrastructures
, 2013 The DASISH WP7 brings together representatives from the five social sciences and humanities European Research Infrastructure Consortia (ERICS) to produce training modules and workshops for infrastructure projects on research data management, long-term digital preservation and data reuse.
Alexia Katsanidou, Laurence Horton
openaire +2 more sources