Results 121 to 130 of about 72,558,504 (293)

Preserving Linked Data Integrity on the Semantic Web by application of techniques from Hypermedia

This report presents a Literature Review of past work in Hypertext link integrity and current work in the emerging area of Semantic Web link integrity.
Vesse, Robert
core   +1 more source

Ground Strength Test Technique of Variable-Camber Wing Leading Edge

Biomimetics
Morphing wing technology is crucial for enhancing the flight performance of aircraft. To address the monitoring challenges of full-scale variable-camber leading edges under flight conditions, this study introduces a ground-based strength testing ...
Shanshan Li, Xianmin Chen, Zhigang Wang, Yuanbo Liang   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Teaching research integrity : a manual of good practices

This article addresses the critical need for effective teaching strategies in research integrity (RI), acknowledging widespread uncertainty among educators on the best approach.
Priess-Buchheit, Julia, Blom, Fenneke, Groenink, Lucianne, Ristic, Dragana Ignjatovic, Asaduzzaman, Muhammad, Iphofen, Ron, Gruber, Bernadette, Achermann, Gerald, Salwén, Håkan,, van den Hoven, Mariëtte, Salwen, Hakan, Dwojak-Matras, Agnieszka, Holm, Cyril   +12 more
core   +1 more source

Post-Buckling Failure Mechanism and Optimal Tapered Termination Design for Composite Hat-Stiffened Panels

Aerospace
Composite hat-stiffened panels are widely used in civil aircraft structural design as typical closed-section stiffened components with high load-carrying efficiency.
Guofan Zhang, Chunhua Wan, Liang Chang, Xiaohua Nie   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Data integrity: an often-ignored aspect of safety systems: executive summary [PDF]

Data is all-pervasive and is found in all aspects of modern computer systems, and yet many engineers seem reluctant to recognise the importance of data integrity.
Faulkner, Alastair
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source