Results 101 to 110 of about 72,558,504 (293)

Structural dynamic investigation of frame structure with bolted joints

MATEC Web of Conferences, 2017
Frame structure is widely used in many engineering structures. Besides, vibrational problem is one of the main challenges in industry. Bolted joints are commonly used in industry to connect two or more mechanical parts and it plays a significant role in ...
Izham M.H.N., Abdullah N.A.Z., Zahari S.N., Sani M.S.M.   +3 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Vibration fatigue comparative test and life prediction for titanium alloy connection structures

Hangkong gongcheng jinzhan
A large number of mechanical connection structures in aircraft face vibration fatigue problems，and the evaluation of vibration fatigue performance is the key to determine the service life，safety design and evaluation of the structure.
HE Shi, LIU Xiaochuan, LIU Haihan, LI Kaixiang, BAI Chunyu   +4 more
doaj   +1 more source

Big Research Data Integration

, 2019
The paper presents a vision about a new paradigm of data integration in the context of the scientific world, where data integration is instrumental in exploratory studies carried out by research teams. It briefly overviews the technological challenges to be faced in order to successfully carry out the traditional approach to data integration.
Bartalesi Lenzi V, Meghini C, Thanos C
openaire   +4 more sources

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Research on influence law of circuit parameters on heating characteristics of graphite heating elements

Hangkong gongcheng jinzhan
Circuit parameters are the decisive factors for the heating performance of graphite heating elements，and the research on the influence of circuit parameters is the basis for the design of high-performance and high-reliability graphite heaters.
LI Junpeng, LI Shiping, WANG Zhenya, CONG Linhua, WU Jingtao   +4 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Australia's National Integrity System: The Blueprint for Action

, 2020
Three year National Integrity System Assessment of Australia supported by the Australian Research Council, Transparency International Australia, Queensland Crime and Corruption Commission, Queensland Integrity Commissioner, NSW Ombudsman and Tasmanian ...
Coghill, Ken, Graycar, Adam, Brown, Alexander, Kelly, Kym, Prenzler, Tim, Ankamah, Samuel, McMillan, John, Ransley, Janet   +7 more
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