Results 81 to 90 of about 72,558,504 (293)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Impact of land-use and fecal contamination on Escherichia populations in environmental samples
Scientific ReportsUnderstanding the composition of complex Escherichia coli populations from the environment is necessary for identifying strategies to reduce the impacts of fecal contamination and protect public health.
Adrian L. Cookson +7 more
doaj +1 more source
, 2017 Research integrity issues fill the academic news, and include plagiarism, data falsification and image manipulation. Integrity violations are complex because of the gray zones between where bad practice ends and genuine malpractice begin. No real consensus exists about the boundaries, even though many people have strong opinions. The goal of this panel
openaire +3 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Failure Analysis of Large-Scale Composite Fuselage Panels Under Combined Loads
AerospaceThe fuselage serves as the primary component of commercial aircraft. The strength reliability of fuselage panels is therefore crucial for commercial aircraft.
Fei Yuan +5 more
doaj +1 more source
Integrating reflexivity into livelihoods research [PDF]
Progress in Development Studies, 2010 Much development research is not explicit about its methodology or philosophical foundations. Based on the extended case method of Burawoy and the philosophy of critical realism, this article discusses a methodological approach for reflexive livelihoods research that overcomes the unproductive social science dualism of positivism and social ...
openaire +6 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Experimental and simulation study on explosion impact of a typical wall panel structure
Hangkong gongcheng jinzhanThe damage effect of the explosion shock wave generated by the explosion of the air to air missile warhead on the aircraft skin structure is influenced by various factors，and the function mechanism is relatively com plex，so that a large number of ...
ZHOU Jiayu +5 more
doaj +1 more source
Scientific integrity in research methods [PDF]
Frontiers in Psychology, 2015 Recent cases of research misconduct have prompted psychologists to suggest that there is too much vulnerability in the research process (e.g., Simmons et al., 2011; Pashler and Harris, 2012). Regardless of whether this is the case, ensuring the integrity of a discipline requires a clear understanding of what conventions and norms define the research ...
openaire +3 more sources