Results 91 to 100 of about 72,558,504 (293)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Rare genetic diseases associated with G-quadruplex-induced replication stress

Communications Biology
DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substantial barrier for passage
Lauren M. Herr, Swagata Mukhopadhyay, Olivia M. Anderson, Tucker H. Couch, Cate M. Jones, Robert M. Brosh, Martina Rossi   +6 more
doaj   +1 more source

The Singapore Statement on Research Integrity [PDF]

Croatian Medical Journal, 2010
Statement of responsibility in science of the 2nd World Congress participans on responsible conduct of ...
openaire   +3 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Geoethics: A Challenge for Research Integrity in Geosciences

, 2015
Geoethics reflects the intersection of geology, sociology and philosophy and frequently focuses on important environmental issues and problems often related to natural risk management and mitigation.
Peppoloni, S., Silvia Peppoloni, Giuseppe Di Capua, Bobrowsky, P., Peter Bobrowsky, Di Capua, G.   +5 more
core   +1 more source

Research progress of ultrasonic in-situ nondestructive testing technology for aircraft structure

Journal of Aeronautical Materials
Damage detection is a critical link of aviation equipment development，field operation and maintenance，which directly affects the development process and service safety of aircraft structure.
ZHANG Wei, FAN Junling, ZHAN Shaozheng, YANG Pengfei, JIA Wenbo   +4 more
doaj   +1 more source

Integrity in research and publication

Revista Odonto Ciência (Online), 2010
A the concept of integrity in human actions is universal and inherent to any relationship in a civilized society, some guidance should be given to specific situations to set standards of good practice. In times of great academic pressure to publish, double care is necessary to preserve the integrity of research and to prevent publication misconduct ...
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source