Results 51 to 60 of about 1,472,859 (309)

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase

Biomolecules, 2023
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer.
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Calculation method of radiation heat flux field for quartz lamp array for the constant diameter cabins of missile

Xibei Gongye Daxue Xuebao
A rapid calculation method was proposed for the heat flux field of the cylindrical quartz lamp array for the ground thermal test of the constant diameter cabin of missile under multi-elements mesh for the semi-cylinder of the filament.
ZHANG Xiaoxiao, WANG Binwen, YAO Chisen, LI Xinxin, WU Jingtao   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Design and Verification of Multi-Mode Variable Camber Wing Trailing Edge

Engineering Proceedings
By changing the aerodynamic shape of the trailing edge of its wing, an aircraft can achieve lift and drag reduction during takeoff and landing and continuously achieve better aerodynamic efficiency while cruising, which plays an important role in the ...
Yifei Lu, Zhigang Wang, Qi Wu, Yu Yang, Gang Liu   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Geoethics: A Challenge for Research Integrity in Geosciences

, 2015
Geoethics reflects the intersection of geology, sociology and philosophy and frequently focuses on important environmental issues and problems often related to natural risk management and mitigation.
Peppoloni, S., Silvia Peppoloni, Giuseppe Di Capua, Bobrowsky, P., Peter Bobrowsky, Di Capua, G.   +5 more
core   +1 more source

An Efficient High-Frequency Design Methodology for APU Inlet Mufflers Based on Axial Segmentation and Optimal Frequency Selection

Aerospace
The International Civil Aviation Organization (ICAO) sets strict limits for aircraft ramp noise, a key source of which is Auxiliary Power Unit (APU) inlet noise.
Dongwen Xue, Qun Yan, Yong Zheng, Jiafeng Yang, Yonghui Chen   +4 more
doaj   +1 more source

Integrating Meteorology into Research on Migration [PDF]

Integrative and Comparative Biology, 2010
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Shamoun-Baranes, J., Bouten, W., van Loon, E.E.   +2 more
openaire   +5 more sources