Results 51 to 60 of about 72,558,504 (293)

Extreme thermal load generation method for high-temperature structures in atmospheric environment

Xibei Gongye Daxue Xuebao
For addressing the severe aerodynamic thermal load simulation challenge of hypersonic aircraft in ground tests, an extreme thermal load generation method based graphite for high-temperature structures in atmospheric environment is proposed.
WANG Binwen, ZHANG Yi, QIN Qiang, CHEN Hong, WU Jingtao   +4 more
doaj   +1 more source

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase

Biomolecules, 2023
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer.
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Integrating research into practice

Journal of the Medical Library Association, 2016
None
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Calculation method of radiation heat flux field for quartz lamp array for the constant diameter cabins of missile

Xibei Gongye Daxue Xuebao
A rapid calculation method was proposed for the heat flux field of the cylindrical quartz lamp array for the ground thermal test of the constant diameter cabin of missile under multi-elements mesh for the semi-cylinder of the filament.
ZHANG Xiaoxiao, WANG Binwen, YAO Chisen, LI Xinxin, WU Jingtao   +4 more
doaj   +1 more source

Study on optimization method of the modular reconfigurable UAV's wing structure

Hangkong gongcheng jinzhan, 2023
The design of the modular reconfigurable unmanned aircraft vehicle (UAV) has complex conditions and multiple constraints, and it is necessary to obtain the optimal scheme by means of the research on suitable optimiza-tion method according to different ...
LUO Lilong, GUO Wenjie, CHANG Liang
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Design and Verification of Multi-Mode Variable Camber Wing Trailing Edge

Engineering Proceedings
By changing the aerodynamic shape of the trailing edge of its wing, an aircraft can achieve lift and drag reduction during takeoff and landing and continuously achieve better aerodynamic efficiency while cruising, which plays an important role in the ...
Yifei Lu, Zhigang Wang, Qi Wu, Yu Yang, Gang Liu   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source