Results 41 to 50 of about 1,570,252 (311)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Intellectual freedom principles for academic libraries : an interpretation of the Library Bill of Rigths

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 1999
Declaració sobre els principis generals de llibertat intel•lectual que s’han d’aplicar a una biblioteca universitària.
Association of College and Research Libraries
doaj  

Library funding for open access at KU Leuven

open access: yesInsights: The UKSG Journal, 2022
As main buyers of scholarly literature, research libraries have always provided essential economic support for sustaining the market of academic publishing. With the switch to open access (OA), libraries are now faced with transitioning this support from
Demmy Verbeke, Laura Mesotten
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Merry work: libraries and citizen science

open access: yesInsights: The UKSG Journal, 2018
This article highlights important new opportunities for libraries by analysing the roles they could potentially play in citizen science projects. Citizen science is one of the eight pillars of open science identified by the Open Science Policy Platform ...
Tiberius Ignat   +6 more
doaj   +1 more source

The Changing Role of the Middle Manager in Research Libraries [PDF]

open access: yes, 1992
published or submitted for ...
Sullivan, Maureen
core  

What Does it Take to Make Discovery a Success?: A Survey of Discovery Tool Adoption, Instruction, and Evaluation Among Academic Libraries [PDF]

open access: yes, 2017
Discovery tools have been widely adopted by academic libraries, yet little information exists that connects common practices regarding discovery tool implementation, maintenance, assessment, and staffing with conventions for research and instruction. The
Allison, Megan   +3 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Thirty Years of Change in the UK and in Europe After 1989: A Personal Perspective

open access: yesBibliothek
The political events of 1989 had reverberations throughout Europe and beyond. For research libraries, new horizons for researchers and new forms of co-operation opened up, enabled by technology, assisted by the European Commission and its programmes, and
Matheson Ann
doaj   +1 more source

Artificial Intelligence in PhD education: New perspectives for research libraries

open access: yesLiber Quarterly: The Journal of European Research Libraries
Artificial intelligence (AI) will drastically influence and change the working methods of scholars and researchers. This paper presents findings from a broad, national survey and a workshop focusing on the challenges and opportunities the advancement of
Michael Grote   +2 more
doaj   +1 more source

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