Results 91 to 100 of about 2,517,674 (258)

Using prospective research methodology to understand policy advocacy for sexual and reproductive health and rights (SRHR). [PDF]

Sex Reprod Health Matters, 2023
Clark S, Abdi S, Chingarande SD, Koshin SA, Khadduri R, le May A.   +5 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Ranking Research Methodology by Risk - a cross-sectional study to determine the opinion of research ethics committee members. [PDF]

Syst Rev, 2023
Kolstoe SE, Durning J, Yost J, Aleksandrova-Yankulovska S.   +3 more
europepmc   +1 more source

Integrating research methodology and training into the undergraduate medical curriculum – students’ perspectives of Jeddah and Rabigh Medical Colleges, King Abdulaziz University, Kingdom Of Saudi Arabia

, 2015
Z Alamin, Osama Almutairi, Hassan Allam, Majd Alnawwar, Hazem Atta   +4 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Botulinum Toxin in Aesthetic Medicine: A Bibliometric Analysis of Research Trends and Methodological Quality of the Top 100 Cited Publications [PDF]

Zhen Yu Wong, Pegah Damavandi, M.A. Richards, Pojsakorn Danpanichkul, Oluwatobi Adegboye, Ryan Faderani, Muholan Kanapathy, Afshin Mosahebi   +7 more
openalex   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Consciousness of the consequences of smoking cigarettes and the prevalence of cigarette smoking among medical students

Journal of Education, Health and Sport, 2018
Cigarettes are composed of toxic substances that result in the development of chronic obstructive pulmonary disease (COPD) and cardiovascular diseases. Smoking is also a risk factor of many cancers.
Agnieszka Radzka, Krystian Ciechański, Jędrzej Tkaczyk, Klaudia Brożyna, Halina Piecewicz-Szczęsna   +4 more
doaj  

Methodology of research on drivers perception at level crossings [PDF]

, 2018
Anna Kobaszyńska-Twardowska, Marta Galant, Adrian Gill, Piotr Smoczyński, Adam Kadziński   +4 more
openalex   +1 more source