Results 91 to 100 of about 25,687,414 (343)
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Alchemy methodology: transforming qualitative research
, 2016 Alchemy Methodology is an application of Husserl's Transcendental Phenomenology, which offers a philosophical foundation for doing research. It returns to the original principles of pure phenomenology, and presents a step by step approach to inquiry ...
Vallack, Jocene
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Decolonizing research with the Fala methodology
When Indigenous peoples become the researchers and not merely the researched, the process of creating new knowledge is transformed. Decolonization focuses on Indigenous ways of engaging with communities and their knowledge systems, on their terms.
Faingaa-Manu Sione, Inez
core +1 more source
Barriers to Early Breast Cancer Diagnosis in Sudanese Women Before the War
Breast Cancer: Targets and TherapyHana Eltayeb Salih Elamin,1 Hind Eltayeb Salih Elamin,2 Ghada Omer Hamad Abd El-Raheem,3 Mounkaila Noma1 1High Diploma in Research Methodology and Biostatistics, University of Medical Sciences and Technology UMST, Khartoum City, Khartoum State, Sudan ...
Elamin HES +3 more
doaj
PLoS Medicine, 2016 BackgroundDentists prescribe approximately 10% of antibiotics dispensed in UK community pharmacies. Despite clear clinical guidance, dentists often prescribe antibiotics inappropriately.
Paula Elouafkaoui +7 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Vital Role of Research Methodology in Addressing the Research Questions
, 2022 Research methodology is an essential component of the research process. It provides a structured approach to conducting research, ensures the reliability and validity of research findings, facilitates communication and collaboration, and helps to advance
Bahishti, Adam A
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source