Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Clinical research methodology process: what has changed with COVID-19? [PDF]
Eur Heart J Suppl, 2022 Tavazzi L.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Vignette Research Methodology: An Essential Tool for Quality Improvement Collaboratives. [PDF]
Healthcare (Basel), 2022 Payton KSE, Gould JB.
europepmc +1 more source
METHODOLOGICAL INSIGHTS FROM RESEARCHING TEMPORALITY IN FAMILIES WITH TEENAGE CHILDREN
, 2014 Sophie Sarre, Jo Moran‐Ellis
openalex +1 more source
Q Methodology as an Innovative Addition to Bullying Researchers’ Methodological Repertoire [PDF]
, 2022 Adrian Lundberg, Lisa Hellström
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Building a Low-Cost Wireless Biofeedback Solution: Applying Design Science Research Methodology. [PDF]
Sensors (Basel), 2023 Cheng CF, Lin CJ.
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
The difference between concealment and blinding in clinical trials and why both are important. A reply to Garg and Mickenautsch, BMC Medical Research Methodology (2022) 22:17. [PDF]
BMC Med Res Methodol, 2023 Lyden P +7 more
europepmc +1 more source