Results 121 to 130 of about 7,011,032 (315)

A case for the use of the ability-in language user-in context orientation in game-based assessment

Language Testing in Asia, 2017
Dynamic assessments in general, and game-based assessment (GBA) specifically, compel us to rethink prevailing language testing conceptualizations of context.
Alexandra Lay, Elizabeth Patton, Micheline Chalhoub-Deville   +2 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Identifying research priorities for effective retention strategies in clinical trials

Trials, 2017
Background The failure to retain patients or collect primary-outcome data is a common challenge for trials and reduces the statistical power and potentially introduces bias into the analysis. Identifying strategies to minimise missing data was the second
Anna Kearney, Anne Daykin, Alison R. G. Shaw, Athene J. Lane, Jane M. Blazeby, Mike Clarke, Paula Williamson, Carrol Gamble   +7 more
doaj   +1 more source

Project Retrosight. Understanding the returns from cardiovascular and stroke research: Methodology Report [PDF]

, 2011
Copyright @ 2011 RAND Europe. All rights reserved. The full text article is available via the link below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the ...
Buxton, MJ, Grant, J, Hanney, S, Pollitt, A, Wooding, S   +4 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Dealing with Big Data [PDF]

arXiv, 2016
This book chapter attempts to counter anxieties in the humanities and social science about the role of big data in research by focusing on approaches which, by being firmly grounded in the traditional values of disciplines, enhance existing methods to produce fruitful research.
arxiv  

Che-Yong() Logic and Research Methodology. [PDF]

Dev Reprod, 2022
Yun Y.
europepmc   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

An Audit and Feedback Intervention for Reducing Antibiotic Prescribing in General Dental Practice: The RAPiD Cluster Randomised Controlled Trial.

PLoS Medicine, 2016
BackgroundDentists prescribe approximately 10% of antibiotics dispensed in UK community pharmacies. Despite clear clinical guidance, dentists often prescribe antibiotics inappropriately.
Paula Elouafkaoui, Linda Young, Rumana Newlands, Eilidh M Duncan, Andrew Elders, Jan E Clarkson, Craig R Ramsay, Translation Research in a Dental Setting (TRiaDS) Research Methodology Group   +7 more
doaj   +1 more source

(Optimal) governance of research support by “Survey Methodology” [PDF]

Survey research is an integral element of modern social science. The infrastructure in terms of research institute, surveys, conferences and journals has greatly improved over the past 20 years and recently several initiatives have gained momentum even ...
Marek Fuchs
core