Results 71 to 80 of about 7,011,032 (315)

Designing Explainable Predictive Machine Learning Artifacts: Methodology and Practical Demonstration [PDF]

arXiv, 2023
Prediction-oriented machine learning is becoming increasingly valuable to organizations, as it may drive applications in crucial business areas. However, decision-makers from companies across various industries are still largely reluctant to employ applications based on modern machine learning algorithms.
arxiv  

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Research methodology

This research uses the case study of Rwanda to gain insight into different narrative elements found in post-conflict history education. It was chosen as the case-study country for several reasons. Rwanda experienced a moratorium on covering sensitive topics to allow local experts to determine the best way to depict recent history with help from the ...
Dr. CHANDRA SEKHA PATTNAIK, Dr. Saibabu Neyyila, Mrs. Kallepalli Madhavi, Mrs.Pranaya. Deekonda, P. S D Bhimaraju   +4 more
  +8 more sources

Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia

Journal of Education, Health and Sport, 2020
Introduction and purpose: Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness,  nonrestorative sleep, anxiety, depression and ...
Małgorzata Drozd, Magdalena Marzęda, Agnieszka Blicharz, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Hepatotoxicity of anabolic androgenic steroids in sport

Journal of Education, Health and Sport, 2020
Introduction and purpose: Anabolic-androgenic steroids (AAS) abuse is a common practice among professional as well as recreational athletes. The prevalence of this phenomenon seems to be continuously escalating, too.
Michał Jakub Sekuła, Blanka Świerczyńska, Krzysztof Smoluchowski, Adrian Undziakiewicz, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Secure Software Development Methodologies: A Multivocal Literature Review [PDF]

arXiv, 2022
In recent years, the number of cyber attacks has grown rapidly. An effective way to reduce the attack surface and protect software is adoption of methodologies that apply security at each step of the software development lifecycle. While different methodologies have been proposed to address software security, recent research shows an increase in the ...
arxiv  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Beriberi disease – a picture of thiamine deficiency in underdeveloped and highly developed countries

Journal of Education, Health and Sport, 2020
Introduction and purpose: Thiamin (Vitamin B1) is a water-soluble vitamin. It plays an important role in many biological processes, mainly in glucose metabolism. Its deficiency is called beriberi disease.
Agnieszka Blicharz, Magdalena Marzęda, Małgorzara Drozd, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Evaluating a Department’s Research: Testing the Leiden Methodology in Business and Management [PDF]

, 2013
The Leiden methodology (LM), also sometimes called the “crown indicator”, is a quantitative method for evaluating the research quality of a research group or academic department based on the citations received by the group in comparison to averages for ...
Abramo, Aksnes, Bornmann, Bornmann, Evangelia A.E.C.G. Lipitakis, Horrobin, John Mingers, Leydesdorff, Leydesdorff, Leydesdorff, Lundberg, Mahdi, Meho, Mingers, Mingers, Mingers, Moed, Moed, Moed, Moed, Moxham, Nederhof, Nederhof, Opthof, Rinia, Schubert, Todeschini, Van Leeuwen, van Raan, van Raan, van Raan, van Raan, van Raan, van Raan, Van Veller, Walters, Waltman, Waltman   +37 more
core   +1 more source