Results 71 to 80 of about 7,775,610 (280)

Problems of methodology and explanation in word order universals research [PDF]

, 2010
Ever since the publication of Greenberg 1963, word order typologists have attempted to formulate and refine implicational universals of word order so as to characterize the restricted distribution of certain word order patterns, and in some cases have ...
LaPolla, Randy J.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Beriberi disease – a picture of thiamine deficiency in underdeveloped and highly developed countries

Journal of Education, Health and Sport, 2020
Introduction and purpose: Thiamin (Vitamin B1) is a water-soluble vitamin. It plays an important role in many biological processes, mainly in glucose metabolism. Its deficiency is called beriberi disease.
Agnieszka Blicharz, Magdalena Marzęda, Małgorzara Drozd, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia

Journal of Education, Health and Sport, 2020
Introduction and purpose: Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness,  nonrestorative sleep, anxiety, depression and ...
Małgorzata Drozd, Magdalena Marzęda, Agnieszka Blicharz, Jakub Czarnota, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Conditional Power and Model Selection Based Sample Size Reestimation with Type I Error Recalibration

Epidemiology, Biostatistics and Public Health
Introduction The sample size estimation at study design depends on initial assumptions regarding the target power, treatment effect, accrual/follow-up duration and the underlying exponential distribution for time-to-event outcomes.
Michele Pio Di Palma, Francesca Galli , Eliana Rulli   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Research Methodology Through Writing Research Proposal Retrospectively by Combining Classroom Discussion and Collaborative Working Group in Lesson Study [PDF]

, 2015
Lesson Study (LS) was conducted aiming at: (1) describing the ideal steps in combining classroom discussion and collaborative working group in effort to improve students' comprehension on writing biology research proposal that is arranged retrospectively;
Hindun, I. (Iin), Husamah, H. (Husamah), Purwanti, E. (Ely), Rofieq, A. (Ainur), Wahyuni, S. (Sri)   +4 more
core  

Exploring the IT usage in SMEs from New Zealand, Columbia and Chile using action-research methodology [PDF]

, 2012
The theory on the adoption and use of information technology (IT) in small and medium enterprises (SMEs) is abundant. However, methodologically speaking, action-research (AR) has been little explored as a method of construction of this theory, despite ...
Cataldo, Alejandro, McQueen, Robert J., Sepúlveda, Marcos   +2 more
core   +2 more sources