Results 111 to 120 of about 1,735,729 (314)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Dealing with Big Data [PDF]

open access: yesarXiv, 2016
This book chapter attempts to counter anxieties in the humanities and social science about the role of big data in research by focusing on approaches which, by being firmly grounded in the traditional values of disciplines, enhance existing methods to produce fruitful research.
arxiv  

Communicative Methodology of Research with Minority Groups: The Roma Women’s Movement [PDF]

open access: yes, 2013
Today's society has a dialogic and communicative base. Social sciences and social research have to conform to this base that is marking our society.
de Botton, L.   +3 more
core   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers   +7 more
wiley   +1 more source

Impact of social context on human facial and gestural emotion expressions

open access: yesiScience
Summary: Humans flexibly adapt expressions of emotional messages when interacting with others. However, detailed information on how specific parts of the face and hands move in socio-emotional contexts is missing.
Raphaela Heesen   +6 more
doaj  

Acculturation and Naturalization: Insights From Representative and Longitudinal Migration Studies in Germany

open access: yesFrontiers in Psychology, 2019
In recent years, Western countries have been experiencing a growing wave of immigration. Due to this development, these countries are facing great challenges in successfully integrating large numbers of immigrants and in preserving social cohesion ...
Débora B. Maehler   +2 more
doaj   +1 more source

Measuring the benefits of social science research: [PDF]

open access: yes
This paper addresses two questions: The first is "What are the benefits of social science research?"; the second is "How should they be measured?" The response to the first is that, as with research in the physical sciences, the benefits should be ...
Smith, Vincent H.
core  

Integrated Approach in “Social Research of Science” as a Methodological Problem

open access: yesProcedia - Social and Behavioral Sciences, 2015
AbstractSociology of scientific knowledge (SSK) is a study of science as a social activity, especially dealing with the social conditions and effects of science and with the social structures and processes of scientific activity. The theorists of Sociology of Scientific Knowledge consider sociological factors as influencing all beliefs in science ...
openaire   +2 more sources

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