Results 121 to 130 of about 2,566,888 (342)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Integrated Scenario-based Design Methodology for Collaborative Technology Innovation [PDF]
The paper presents a scenario-based methodology developed and tested throughout cooperative research and development projects. It is aimed at supporting information technology innovation with an end-to-end Human and Social Sciences assistance.
Fabrice Forest +2 more
core
Lab experiments are a major source of knowledge in the social sciences [PDF]
, 2009 Laboratory experiments are a widely used methodology for advancing causal knowledge in the physical and life sciences. With the exception of psychology, the adoption of laboratory experiments has been much slower in the social sciences, although during ...
Falk, Armin, Heckman, James Joseph
core
Del rigor en la Ciencia Política: algunas reflexiones sobre metodología de la investigación.
Colombia Internacional, 2007 During the first semester of 2006, political science students from the University of the Andes held their second symposium. One of the papers presented and its corresponding critique made by one of the department’s professors is here transcribed.
Santiago Olivella
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
, 2004 There are a number of papers in the journal that reflect a trend in environmental education towards deliberating recuperative, relational epistemologies.
Lotz-Sisitka, Heila 1965-
core +1 more source
iScienceSummary: The 15 January 2022, Hunga Tonga Hunga Ha’apai volcanic eruption generated a tsunami that spread across the Pacific Ocean and prompted a tsunami advisory in Aotearoa New Zealand (NZ).
Sara E. Harrison +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Universitas Humanística, 2007 The main source of difficulties we find in social sciences to accumulate knowledge comes from fusioning the question of what to research with the question of how to solve research questions.
Juan Camilo Plata Caviedes
doaj