Results 121 to 130 of about 1,735,729 (314)

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

The impact of climatic factors on negative sentiments: An analysis of human expressions from X platform in Germany

open access: yesiScience
Summary: Expressions in social media can provide a rapid insight into people’s reactions to events, such as periods of climatic stress. This study explored the link between climatic stressors and negative sentiment on the X platform in Germany to inform ...
Tareq Al-Ahdal   +6 more
doaj  

Developing the egovernment research agenda [PDF]

open access: yes, 2007
This paper presents an exploratory research project to determine the needs for future eGovernment research. The project aimed particularly at getting relevant stakeholder views as a contrast to the received academic wisdom or political rhetoric.
Elliman, T, Irani, Z, Jackson, P
core   +1 more source

Mapping Diversity of Publication Patterns in the Social Sciences and Humanities: An Approach Making Use of Fuzzy Cluster Analysis [PDF]

open access: yes, 2016
<b>Purpose:</b> To present a method for systematically mapping diversity of publication patterns at the author level in the social sciences and humanities in terms of publication type, publication language and co-authorship.<br><b ...
Arie Weeren   +2 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Advancing health equity in the aftermath of COVID-19: Confronting intensifying racial disparities

open access: yesiScience
Summary: The COVID-19 pandemic has exposed and exacerbated the persistent racial and ethnic health disparities in the United States. The pandemic has also had profound spillover effects on other aspects of health and wellbeing, such as mental health ...
Kristen R. Prentice   +3 more
doaj  

Exploiting Tweet Sentiments in Altmetrics Large-Scale Data [PDF]

open access: yesarXiv, 2020
This article aims to exploit social exchanges on scientific literature, specifically tweets, to analyse social media users' sentiments towards publications within a research field. First, we employ the SentiStrength tool, extended with newly created lexicon terms, to classify the sentiments of 6,482,260 tweets associated with 1,083,535 publications ...
arxiv  

A methodological approach to evaluate elderly-robot interactions [PDF]

open access: yes, 2018
The relevance in the study of interaction between elderly and robots may depend on the choice of activities that robots can be developed to perform and the assessment of their impact and importance for older people.
Gonçalves, Paulo   +4 more
core  

Methodological Aspects of Pedagogy’s Two-Discipline Location [PDF]

open access: yes, 2020
The area of pedagogy research penetration is situated in the disciplines of social sciences and humanities. The answer to the question what methodological consequences this brings to the practice of pedagogy favours the broadening of the ethodological ...
Urbaniak-Zając, Danuta
core   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

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