Results 51 to 60 of about 988,477 (336)

Methods matter: Exploring how expectations influence common actions

iScience
Summary: Behavior in controlled laboratory studies is not always representative of what people do in daily life. This has prompted a recent shift toward conducting studies in natural settings.
Andrea Ghiani, David Mann, Eli Brenner
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Basics of the methodology of scientific-research work - Mihael Antolović, Snežana Štrangarić: Introduction to the Methodology of Scientific-Research Work: Research Methods and Techniques in Social Sciences: Basics of Academic Writing, Faculty of Education, Sombor, 2021 [PDF]

, 2022
Živković Vesna R.
openalex   +1 more source

Assessing the impact of armed conflict on the progress of achieving 17 sustainable development goals

iScience
Summary: With global armed conflicts reaching a 30-year high in 2023, understanding their impact on the progress of Sustainable Development Goals (SDGs) is crucial.
Di Wang, Mengmeng Hao, Ning Li, Dong Jiang   +3 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Active learning-based systematic reviewing using switching classification models: the case of the onset, maintenance, and relapse of depressive disorders

Frontiers in Research Metrics and Analytics, 2023
IntroductionThis study examines the performance of active learning-aided systematic reviews using a deep learning-based model compared to traditional machine learning approaches, and explores the potential benefits of model-switching strategies ...
Jelle Jasper Teijema, Laura Hofstee, Marlies Brouwer, Jonathan de Bruin, Gerbrich Ferdinands, Jan de Boer, Pablo Vizan, Sofie van den Brand, Claudi Bockting, Rens van de Schoot, Ayoub Bagheri   +10 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Observational studies of exposure to tobacco and nicotine products: Best practices for maximizing statistical precision and accuracy

iScience
Summary: Non-randomized observational studies can track risk-induction and -reduction associated with real-world use of non-combusted nicotine and tobacco products.
Gal Cohen, Steven Cook
doaj   +1 more source

The impact of the COVID-19 pandemic on enrollment in undergraduate health-related studies in Spain

BMC Medical Education, 2023
The aim of this study was to determine whether the pandemic has reinforced the choice of pursuing health-related bachelor’s degrees, and to identify underlying factors that could contribute to that impact.
Jaume-Miquel March-Amengual, Irene Cambra-Badii, Consolación Pineda Galán, Ester Busquets-Alibés, Montse Masó Aguado, Anna Ramon-Aribau, Lydia Feito Grande, Agustí Comella Cayuela, Nuria Terribas i Sala, Elena Andrade-Gómez, Naiara Martínez-Perez, Javier Jerez-Roig   +11 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source