Results 181 to 190 of about 87,581,544 (292)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Correction: Model-based cost-impact analysis of a diagnostic test for patients with community-acquired pneumonia in Canada

BMC Infectious Diseases
Brittany Humphries, Yuan Sun, Jeffrey Pernica, Feng Xie   +3 more
doaj   +1 more source

Cross-cultural validation of the attitudes toward research methods scale in teacher education: evidence from a Turkish sample including music teacher candidates. [PDF]

Front Psychol
Sen C, Özer Z.
europepmc   +1 more source

Searching for Research Methods [PDF]

Scandinavian Journal of Primary Health Care, 1986
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Reflections on the use of qualitative research methods: it's not 'fluffy'. [PDF]

Br J Gen Pract
Chew-Graham CA.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Research Methods for the Analysis of Visual Emotion Cues in Animals: A Workshop Report. [PDF]

Animals (Basel)
Correia-Caeiro C, Zamansky A, Karl S, Bremhorst A.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods. [PDF]

Nat Commun
Smothers CG, Gandhi SA, Chang JH, Tahir SM, Kelley J, Wang E, Fareed K, Mack H, Dong C, Witort M, Armentrout BL, Crawford D, Wang J, Williams K, Bud Z, Horvat-Davey C, Winkelman C, Martha SR, Schrock JW, Ardelt AA, O'Connell GC.   +20 more
europepmc   +1 more source